Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects

Ewing sarcoma (ES) is an aggressive malignancy driven by an oncogenic fusion protein, EWS-FLI1. Neuropeptide Y (NPY), and two of its receptors, Y1R and Y5R are up-regulated by EWS-FLI1 and abundantly expressed in ES cells. Paradoxically, NPY acting via Y1R and Y5R stimulates ES cell death. Here, we...

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Detalles Bibliográficos
Autores principales: Tilan, Jason U., Lu, Congyi, Galli, Susana, Izycka-Swieszewska, Ewa, Earnest, Joshua Patrick, Shabbir, Asim, Everhart, Lindsay M., Wang, Shuo, Martin, Samantha, Horton, Meredith, Mahajan, Akanksha, Christian, David, O'Neill, Alison, Wang, Hongkun, Zhuang, Tingting, Czarnecka, Magdalena, Johnson, Michael D., Toretsky, Jeffrey A., Kitlinska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926843/
https://www.ncbi.nlm.nih.gov/pubmed/24318733

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