Disarmed by density: A glycolytic break for immunostimulatory dendritic cells?

We observed a cell concentration-dependent differentiation switch among cultured dendritic cells (DCs) triggered by lactic acid, a product of glycolytic metabolism. In particular, while interleukin (IL)-12, IL-23, and tumor necrosis factor α (TNFα)-producing, migratory DCs developed in sparse cultur...

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Detalles Bibliográficos
Autores principales: Nasi, Aikaterini, Rethi, Bence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926870/
https://www.ncbi.nlm.nih.gov/pubmed/24575378
http://dx.doi.org/10.4161/onci.26744
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author Nasi, Aikaterini
Rethi, Bence
author_facet Nasi, Aikaterini
Rethi, Bence
author_sort Nasi, Aikaterini
collection PubMed
description We observed a cell concentration-dependent differentiation switch among cultured dendritic cells (DCs) triggered by lactic acid, a product of glycolytic metabolism. In particular, while interleukin (IL)-12, IL-23, and tumor necrosis factor α (TNFα)-producing, migratory DCs developed in sparse cultures, IL-10-producing, non-migratory DCs differentiated in dense cultures. This points to a novel opportunity for tailoring DC-based anticancer therapies through metabolism modulation in developing DCs.
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spelling pubmed-39268702014-02-26 Disarmed by density: A glycolytic break for immunostimulatory dendritic cells? Nasi, Aikaterini Rethi, Bence Oncoimmunology Author's View We observed a cell concentration-dependent differentiation switch among cultured dendritic cells (DCs) triggered by lactic acid, a product of glycolytic metabolism. In particular, while interleukin (IL)-12, IL-23, and tumor necrosis factor α (TNFα)-producing, migratory DCs developed in sparse cultures, IL-10-producing, non-migratory DCs differentiated in dense cultures. This points to a novel opportunity for tailoring DC-based anticancer therapies through metabolism modulation in developing DCs. Landes Bioscience 2013-12-01 2013-10-22 /pmc/articles/PMC3926870/ /pubmed/24575378 http://dx.doi.org/10.4161/onci.26744 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Nasi, Aikaterini
Rethi, Bence
Disarmed by density: A glycolytic break for immunostimulatory dendritic cells?
title Disarmed by density: A glycolytic break for immunostimulatory dendritic cells?
title_full Disarmed by density: A glycolytic break for immunostimulatory dendritic cells?
title_fullStr Disarmed by density: A glycolytic break for immunostimulatory dendritic cells?
title_full_unstemmed Disarmed by density: A glycolytic break for immunostimulatory dendritic cells?
title_short Disarmed by density: A glycolytic break for immunostimulatory dendritic cells?
title_sort disarmed by density: a glycolytic break for immunostimulatory dendritic cells?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926870/
https://www.ncbi.nlm.nih.gov/pubmed/24575378
http://dx.doi.org/10.4161/onci.26744
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AT rethibence disarmedbydensityaglycolyticbreakforimmunostimulatorydendriticcells

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