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Disarmed by density: A glycolytic break for immunostimulatory dendritic cells?
We observed a cell concentration-dependent differentiation switch among cultured dendritic cells (DCs) triggered by lactic acid, a product of glycolytic metabolism. In particular, while interleukin (IL)-12, IL-23, and tumor necrosis factor α (TNFα)-producing, migratory DCs developed in sparse cultur...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926870/ https://www.ncbi.nlm.nih.gov/pubmed/24575378 http://dx.doi.org/10.4161/onci.26744 |