Invariant NKT cells: Killers and conspirators against cancer

Although invariant natural killer T (iNKT) cells influence antitumor responses indirectly by secreting cytokines and promoting the cytolytic functions of T and NK cells, we find that iNKT cells mediate direct tumoricidal activity in vitro and significantly inhibit tumor growth in vivo, even in the a...

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Detalles Bibliográficos
Autores principales: Bassiri, Hamid, Das, Rupali, Nichols, Kim E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926875/
https://www.ncbi.nlm.nih.gov/pubmed/24575380
http://dx.doi.org/10.4161/onci.27440
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author Bassiri, Hamid
Das, Rupali
Nichols, Kim E
author_facet Bassiri, Hamid
Das, Rupali
Nichols, Kim E
author_sort Bassiri, Hamid
collection PubMed
description Although invariant natural killer T (iNKT) cells influence antitumor responses indirectly by secreting cytokines and promoting the cytolytic functions of T and NK cells, we find that iNKT cells mediate direct tumoricidal activity in vitro and significantly inhibit tumor growth in vivo, even in the absence of other cytotoxic lymphocytes.
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spelling pubmed-39268752014-02-26 Invariant NKT cells: Killers and conspirators against cancer Bassiri, Hamid Das, Rupali Nichols, Kim E Oncoimmunology Author's View Although invariant natural killer T (iNKT) cells influence antitumor responses indirectly by secreting cytokines and promoting the cytolytic functions of T and NK cells, we find that iNKT cells mediate direct tumoricidal activity in vitro and significantly inhibit tumor growth in vivo, even in the absence of other cytotoxic lymphocytes. Landes Bioscience 2013-12-01 2014-01-03 /pmc/articles/PMC3926875/ /pubmed/24575380 http://dx.doi.org/10.4161/onci.27440 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Bassiri, Hamid
Das, Rupali
Nichols, Kim E
Invariant NKT cells: Killers and conspirators against cancer
title Invariant NKT cells: Killers and conspirators against cancer
title_full Invariant NKT cells: Killers and conspirators against cancer
title_fullStr Invariant NKT cells: Killers and conspirators against cancer
title_full_unstemmed Invariant NKT cells: Killers and conspirators against cancer
title_short Invariant NKT cells: Killers and conspirators against cancer
title_sort invariant nkt cells: killers and conspirators against cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926875/
https://www.ncbi.nlm.nih.gov/pubmed/24575380
http://dx.doi.org/10.4161/onci.27440
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