Interferon α interferes with immunological tolerance

The ability of regulatory T cells (Tregs) to promote immunological tolerance represents an important obstacle in cancer immunotherapy. We have recently discovered that the clinically established immunotherapeutic agent interferon α (IFNα) inactivates the suppressive functions of human Tregs. Here, w...

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Detalles Bibliográficos
Autores principales: Becker, Christian, Bopp, Tobias, Steinbrink, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926876/
https://www.ncbi.nlm.nih.gov/pubmed/24575381
http://dx.doi.org/10.4161/onci.27528
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author Becker, Christian
Bopp, Tobias
Steinbrink, Kerstin
author_facet Becker, Christian
Bopp, Tobias
Steinbrink, Kerstin
author_sort Becker, Christian
collection PubMed
description The ability of regulatory T cells (Tregs) to promote immunological tolerance represents an important obstacle in cancer immunotherapy. We have recently discovered that the clinically established immunotherapeutic agent interferon α (IFNα) inactivates the suppressive functions of human Tregs. Here, we outline the mechanisms whereby IFNα mediates this important function and discuss its therapeutic implications for cancer immunotherapy.
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spelling pubmed-39268762014-02-26 Interferon α interferes with immunological tolerance Becker, Christian Bopp, Tobias Steinbrink, Kerstin Oncoimmunology Author's View The ability of regulatory T cells (Tregs) to promote immunological tolerance represents an important obstacle in cancer immunotherapy. We have recently discovered that the clinically established immunotherapeutic agent interferon α (IFNα) inactivates the suppressive functions of human Tregs. Here, we outline the mechanisms whereby IFNα mediates this important function and discuss its therapeutic implications for cancer immunotherapy. Landes Bioscience 2013-12-01 2014-01-03 /pmc/articles/PMC3926876/ /pubmed/24575381 http://dx.doi.org/10.4161/onci.27528 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Becker, Christian
Bopp, Tobias
Steinbrink, Kerstin
Interferon α interferes with immunological tolerance
title Interferon α interferes with immunological tolerance
title_full Interferon α interferes with immunological tolerance
title_fullStr Interferon α interferes with immunological tolerance
title_full_unstemmed Interferon α interferes with immunological tolerance
title_short Interferon α interferes with immunological tolerance
title_sort interferon α interferes with immunological tolerance
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926876/
https://www.ncbi.nlm.nih.gov/pubmed/24575381
http://dx.doi.org/10.4161/onci.27528
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