Towards Quantitation of the Effects of Renal Impairment and Probenecid Inhibition on Kidney Uptake and Efflux Transporters, Using Physiologically Based Pharmacokinetic Modelling and Simulations

BACKGROUND AND OBJECTIVES: The kidney is a major drug-eliminating organ. Renal impairment or concomitant use of transporter inhibitors may decrease active secretion and increase exposure to a drug that is a substrate of kidney secretory transporters. However, prediction of the effects of patient fac...

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Detalles Bibliográficos
Autores principales: Hsu, Vicky, de L. T. Vieira, Manuela, Zhao, Ping, Zhang, Lei, Zheng, Jenny Huimin, Nordmark, Anna, Berglund, Eva Gil, Giacomini, Kathleen M., Huang, Shiew-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927056/
https://www.ncbi.nlm.nih.gov/pubmed/24214317
http://dx.doi.org/10.1007/s40262-013-0117-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927056/
https://www.ncbi.nlm.nih.gov/pubmed/24214317
http://dx.doi.org/10.1007/s40262-013-0117-y

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