Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods

For more than two decades, scientists have been trying to replace the regulatory in vivo Draize eye test by in vitro methods, but so far only partial replacement has been achieved. In order to better understand the reasons for this, historical in vivo rabbit data were analysed in detail and resample...

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Detalles Bibliográficos
Autores principales: Adriaens, Els, Barroso, João, Eskes, Chantra, Hoffmann, Sebastian, McNamee, Pauline, Alépée, Nathalie, Bessou-Touya, Sandrine, De Smedt, Ann, De Wever, Bart, Pfannenbecker, Uwe, Tailhardat, Magalie, Zuang, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927066/
https://www.ncbi.nlm.nih.gov/pubmed/24374802
http://dx.doi.org/10.1007/s00204-013-1156-8

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