Mechanisms and proteins involved in long-distance interactions

Due to advances in genome-wide technologies, consistent distant interactions within chromosomes of higher eukaryotes have been revealed. In particular, it has been shown that enhancers can specifically and directly interact with promoters by looping out intervening sequences, which can be up to seve...

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Autores principales: Maksimenko, Oksana, Georgiev, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927085/
https://www.ncbi.nlm.nih.gov/pubmed/24600469
http://dx.doi.org/10.3389/fgene.2014.00028
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author Maksimenko, Oksana
Georgiev, Pavel
author_facet Maksimenko, Oksana
Georgiev, Pavel
author_sort Maksimenko, Oksana
collection PubMed
description Due to advances in genome-wide technologies, consistent distant interactions within chromosomes of higher eukaryotes have been revealed. In particular, it has been shown that enhancers can specifically and directly interact with promoters by looping out intervening sequences, which can be up to several hundred kilobases long. This review is focused on transcription factors that are supposed to be involved in long-range interactions. Available data are in agreement with the model that several known transcription factors and insulator proteins belong to an abundant but poorly studied class of proteins that are responsible for chromosomal architecture.
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spelling pubmed-39270852014-03-05 Mechanisms and proteins involved in long-distance interactions Maksimenko, Oksana Georgiev, Pavel Front Genet Genetics Due to advances in genome-wide technologies, consistent distant interactions within chromosomes of higher eukaryotes have been revealed. In particular, it has been shown that enhancers can specifically and directly interact with promoters by looping out intervening sequences, which can be up to several hundred kilobases long. This review is focused on transcription factors that are supposed to be involved in long-range interactions. Available data are in agreement with the model that several known transcription factors and insulator proteins belong to an abundant but poorly studied class of proteins that are responsible for chromosomal architecture. Frontiers Media S.A. 2014-02-18 /pmc/articles/PMC3927085/ /pubmed/24600469 http://dx.doi.org/10.3389/fgene.2014.00028 Text en Copyright © 2014 Maksimenko and Georgiev. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Maksimenko, Oksana
Georgiev, Pavel
Mechanisms and proteins involved in long-distance interactions
title Mechanisms and proteins involved in long-distance interactions
title_full Mechanisms and proteins involved in long-distance interactions
title_fullStr Mechanisms and proteins involved in long-distance interactions
title_full_unstemmed Mechanisms and proteins involved in long-distance interactions
title_short Mechanisms and proteins involved in long-distance interactions
title_sort mechanisms and proteins involved in long-distance interactions
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927085/
https://www.ncbi.nlm.nih.gov/pubmed/24600469
http://dx.doi.org/10.3389/fgene.2014.00028
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