Cargando…

Boosting the MHC Class II-Restricted Tumor Antigen Presentation to CD4+ T Helper Cells: A Critical Issue for Triggering Protective Immunity and Re-Orienting the Tumor Microenvironment Toward an Anti-Tumor State

Although the existence of an immune response against tumor cells is well documented, the fact that tumors take off in cancer patients indicates that neoplastic cells can circumvent this response. Over the years many investigators have described strategies to rescue the anti-tumor immune response wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Accolla, Roberto S., Lombardo, Letizia, Abdallah, Rawan, Raval, Goutham, Forlani, Greta, Tosi, Giovanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927100/ https://www.ncbi.nlm.nih.gov/pubmed/24600588 http://dx.doi.org/10.3389/fonc.2014.00032

Ejemplares similares

The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators
por: Forlani, Greta, et al.
Publicado: (2013)

Unveiling the Hidden Treasury: CIITA-Driven MHC Class II Expression in Tumor Cells to Dig up the Relevant Repertoire of Tumor Antigens for Optimal Stimulation of Tumor Specific CD4+ T Helper Cells
por: Forlani, Greta, et al.
Publicado: (2020)

The MHC Class II transactivator CIITA inhibits Tax-1-mediated HTLV-1 expression and NF-kB activation
por: Abdallah, Rawan, et al.
Publicado: (2014)

Optimal MHC-II-restricted tumor antigen presentation to CD4+ T helper cells: the key issue for development of anti-tumor vaccines
por: Accolla, Roberto S, et al.
Publicado: (2012)

The MHC Class II transactivator CIITA inhibits the persistent activation of NF-kB by Tax-1
por: Forlani, Greta, et al.
Publicado: (2015)

CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine
por: Accolla, Roberto S., et al.
Publicado: (2019)

Localization, quantification and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL
por: Raval, Goutham U, et al.
Publicado: (2015)

Localization, quantization and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL
por: Raval, Goutham U, et al.
Publicado: (2015)

Localization, quantization and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL
por: Raval, Goutham U, et al.
Publicado: (2015)

Protective anti-tumor vaccination against glioblastoma expressing the MHC class II transactivator CIITA
por: Celesti, Fabrizio, et al.
Publicado: (2023)

MHC class II transactivator CIITA inhibits Tax-2-mediated HTLV-2 LTR transactivation and viral replication by binding to, and affecting Tax-2 intracellular localization
por: Orlandi, Chiara, et al.
Publicado: (2011)

The MHC-II transactivator CIITA, a viral restriction factor inhibiting the replication of Human T-Cell Lymphotropic Virus Type 1
por: Tosi, Giovanna, et al.
Publicado: (2011)

Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)
por: Baratella, Marco, et al.
Publicado: (2017)

The MHC-II transactivator CIITA inhibits Tat function and HIV-1 replication in human myeloid cells
por: Forlani, Greta, et al.
Publicado: (2016)

Fowlpoxvirus recombinants coding for the CIITA gene increase the expression of endogenous MHC-II and Fowlpox Gag/Pro and Env SIV transgenes
por: Bissa, Massimiliano, et al.
Publicado: (2018)

Tripartite Motif 22 and Class II Transactivator Restriction Factors: Unveiling Their Concerted Action against Retroviruses
por: Forlani, Greta, et al.
Publicado: (2017)

Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication
por: Orlandi, Chiara, et al.
Publicado: (2011)

Reply to the Letter to the Editor: “Importance of nasal secretions in the evaluation of mucosal immunity elicited by mRNA BNT162b2 COVID-19 vaccine” by Francavilla B et al.: Lack of a strong oral mucosal immune response: rethinking the route of COVID-19 vaccine boost administration?
por: Azzi, Lorenzo, et al.
Publicado: (2022)

Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells
por: Alberio, Tiziana, et al.
Publicado: (2018)

Tripartite Motif-Containing Protein 22 Interacts with Class II Transactivator and Orchestrates Its Recruitment in Nuclear Bodies Containing TRIM19/PML and Cyclin T1
por: Forlani, Greta, et al.
Publicado: (2017)

Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1
por: Forlani, Greta, et al.
Publicado: (2019)

HTLV-1 HBZ Viral Protein: A Key Player in HTLV-1 Mediated Diseases
por: Baratella, Marco, et al.
Publicado: (2017)

Re-education of the Tumor Microenvironment With Targeted Therapies and Immunotherapies
por: Ngiow, Shin Foong, et al.
Publicado: (2020)

Epitopes associated with MHC restriction site of T cells. III. I-J epitope on MHC-restricted T helper cells
Publicado: (1987)

CIITA-Transduced Glioblastoma Cells Uncover a Rich Repertoire of Clinically Relevant Tumor-Associated HLA-II Antigens
por: Forlani, Greta, et al.
Publicado: (2021)

Follicular Lymphoma Microenvironment Characteristics Associated with Tumor Cell Mutations and MHC Class II Expression
por: Han, Guangchun, et al.
Publicado: (2022)

Extracellular HSP90 Machineries Build Tumor Microenvironment and Boost Cancer Progression
por: Poggio, Pietro, et al.
Publicado: (2021)

Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency
por: Li, Zhilin, et al.
Publicado: (2022)

Quantitative Analyses of the Tumor Microenvironment Composition and Orientation in the Era of Precision Medicine
por: Petitprez, Florent, et al.
Publicado: (2018)

Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly
por: Li, Shukun, et al.
Publicado: (2020)

Re-Clustering and Profiling of Digestive System Tumors According to Microenvironment Components
por: Wang, Yongwei, et al.
Publicado: (2021)

HTLV-1 Infection and Pathogenesis: New Insights from Cellular and Animal Models
por: Forlani, Greta, et al.
Publicado: (2021)

P-glycoprotein-targeted photodynamic therapy boosts cancer nanomedicine by priming tumor microenvironment
por: Mao, Chengqiong, et al.
Publicado: (2018)

Tumor Microenvironment
por: Arneth, Borros
Publicado: (2019)

Macrophages in Tumor Microenvironments and the Progression of Tumors
por: Hao, Ning-Bo, et al.
Publicado: (2012)

Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment
por: Park, Mi Kyung, et al.
Publicado: (2019)

Copper in the tumor microenvironment and tumor metastasis
por: Kamiya, Tetsuro
Publicado: (2022)

Tumor-Associated Lymphatics Upregulate MHC-II to Suppress Tumor-Infiltrating Lymphocytes
por: Li, Claire Y., et al.
Publicado: (2022)

Interaction of helper T cells and Lyb5+ B cells responding to phosphorylcholine is MHC-restricted
Publicado: (1984)

Transition of tumor-associated macrophages from MHC class II(hi )to MHC class II(low )mediates tumor progression in mice
por: Wang, Benfan, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_u5eo2bbf6c6jicqq3sskohmggd