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Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment

BACKGROUND: 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF) catalyzes the conversion of 4-diphosphocytidyl-2C-methyl-D-erythritol-2-phosphate to 2C-methyl-D-erythritol-2,4-cyclodiphosphate and cytidine monophosphate in production of isoprenoid-precursors via the methylerythritol phosphat...

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Detalles Bibliográficos
Autores principales:	O’Rourke, Patrick EF, Kalinowska-Tłuścik, Justyna, Fyfe, Paul K, Dawson, Alice, Hunter, William N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927217/ https://www.ncbi.nlm.nih.gov/pubmed/24410837 http://dx.doi.org/10.1186/1472-6807-14-1

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