GSK3β is a new therapeutic target for myotonic dystrophy type 1

Myotonic dystrophy type 1 (DM1), an incurable, neuromuscular disease, is caused by the expansion of CTG repeats within the 3′ UTR of DMPK on chromosome 19q. In DM1 patients, mutant DMPK transcripts deregulate RNA metabolism by altering CUG RNA-binding proteins. Several approaches have been proposed...

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Detalles Bibliográficos
Autores principales: Wei, Christina, Jones, Karlie, Timchenko, Nikolai A, Timchenko, Lubov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927489/
https://www.ncbi.nlm.nih.gov/pubmed/25003008
http://dx.doi.org/10.4161/rdis.26555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927489/
https://www.ncbi.nlm.nih.gov/pubmed/25003008
http://dx.doi.org/10.4161/rdis.26555

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