Cargando…
Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3)
Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability and bioactivity. We aimed to examine the association between individual flav...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Nutrition
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927546/ https://www.ncbi.nlm.nih.gov/pubmed/24368432 http://dx.doi.org/10.3945/jn.113.184945 |
_version_ | 1782304139939676160 |
---|---|
author | Zamora-Ros, Raul Forouhi, Nita G. Sharp, Stephen J. González, Carlos A. Buijsse, Brian Guevara, Marcela van der Schouw, Yvonne T. Amiano, Pilar Boeing, Heiner Bredsdorff, Lea Fagherazzi, Guy Feskens, Edith J. Franks, Paul W. Grioni, Sara Katzke, Verena Key, Timothy J. Khaw, Kay-Tee Kühn, Tilman Masala, Giovanna Mattiello, Amalia Molina-Montes, Esther Nilsson, Peter M. Overvad, Kim Perquier, Florence Redondo, M. Luisa Ricceri, Fulvio Rolandsson, Olov Romieu, Isabelle Roswall, Nina Scalbert, Augustin Schulze, Matthias Slimani, Nadia Spijkerman, Annemieke M. W. Tjonneland, Anne Tormo, Maria Jose Touillaud, Marina Tumino, Rosario van der A, Daphne L. van Woudenbergh, Geertruida J. Langenberg, Claudia Riboli, Elio Wareham, Nicholas J. |
author_facet | Zamora-Ros, Raul Forouhi, Nita G. Sharp, Stephen J. González, Carlos A. Buijsse, Brian Guevara, Marcela van der Schouw, Yvonne T. Amiano, Pilar Boeing, Heiner Bredsdorff, Lea Fagherazzi, Guy Feskens, Edith J. Franks, Paul W. Grioni, Sara Katzke, Verena Key, Timothy J. Khaw, Kay-Tee Kühn, Tilman Masala, Giovanna Mattiello, Amalia Molina-Montes, Esther Nilsson, Peter M. Overvad, Kim Perquier, Florence Redondo, M. Luisa Ricceri, Fulvio Rolandsson, Olov Romieu, Isabelle Roswall, Nina Scalbert, Augustin Schulze, Matthias Slimani, Nadia Spijkerman, Annemieke M. W. Tjonneland, Anne Tormo, Maria Jose Touillaud, Marina Tumino, Rosario van der A, Daphne L. van Woudenbergh, Geertruida J. Langenberg, Claudia Riboli, Elio Wareham, Nicholas J. |
author_sort | Zamora-Ros, Raul |
collection | PubMed |
description | Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability and bioactivity. We aimed to examine the association between individual flavanol and flavonol intakes and risk of developing T2D across European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC)–InterAct case-cohort study was conducted in 8 European countries across 26 study centers with 340,234 participants contributing 3.99 million person-years of follow-up, among whom 12,403 incident T2D cases were ascertained and a center-stratified subcohort of 16,154 individuals was defined. We estimated flavonoid intake at baseline from validated dietary questionnaires using a database developed from Phenol-Explorer and USDA databases. We used country-specific Prentice-weighted Cox regression models and random-effects meta-analysis methods to estimate HRs. Among the flavanol subclass, we observed significant inverse trends between intakes of all individual flavan-3-ol monomers and risk of T2D in multivariable models (all P-trend < 0.05). We also observed significant trends for the intakes of proanthocyanidin dimers (HR for the highest vs. the lowest quintile: 0.81; 95% CI: 0.71, 0.92; P-trend = 0.003) and trimers (HR: 0.91; 95% CI: 0.80, 1.04; P-trend = 0.07) but not for proanthocyanidins with a greater polymerization degree. Among the flavonol subclass, myricetin (HR: 0.77; 95% CI: 0.64, 0.93; P-trend = 0.001) was associated with a lower incidence of T2D. This large and heterogeneous European study showed inverse associations between all individual flavan-3-ol monomers, proanthocyanidins with a low polymerization degree, and the flavonol myricetin and incident T2D. These results suggest that individual flavonoids have different roles in the etiology of T2D. |
format | Online Article Text |
id | pubmed-3927546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Society for Nutrition |
record_format | MEDLINE/PubMed |
spelling | pubmed-39275462014-03-04 Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3) Zamora-Ros, Raul Forouhi, Nita G. Sharp, Stephen J. González, Carlos A. Buijsse, Brian Guevara, Marcela van der Schouw, Yvonne T. Amiano, Pilar Boeing, Heiner Bredsdorff, Lea Fagherazzi, Guy Feskens, Edith J. Franks, Paul W. Grioni, Sara Katzke, Verena Key, Timothy J. Khaw, Kay-Tee Kühn, Tilman Masala, Giovanna Mattiello, Amalia Molina-Montes, Esther Nilsson, Peter M. Overvad, Kim Perquier, Florence Redondo, M. Luisa Ricceri, Fulvio Rolandsson, Olov Romieu, Isabelle Roswall, Nina Scalbert, Augustin Schulze, Matthias Slimani, Nadia Spijkerman, Annemieke M. W. Tjonneland, Anne Tormo, Maria Jose Touillaud, Marina Tumino, Rosario van der A, Daphne L. van Woudenbergh, Geertruida J. Langenberg, Claudia Riboli, Elio Wareham, Nicholas J. J Nutr Nutritional Epidemiology Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability and bioactivity. We aimed to examine the association between individual flavanol and flavonol intakes and risk of developing T2D across European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC)–InterAct case-cohort study was conducted in 8 European countries across 26 study centers with 340,234 participants contributing 3.99 million person-years of follow-up, among whom 12,403 incident T2D cases were ascertained and a center-stratified subcohort of 16,154 individuals was defined. We estimated flavonoid intake at baseline from validated dietary questionnaires using a database developed from Phenol-Explorer and USDA databases. We used country-specific Prentice-weighted Cox regression models and random-effects meta-analysis methods to estimate HRs. Among the flavanol subclass, we observed significant inverse trends between intakes of all individual flavan-3-ol monomers and risk of T2D in multivariable models (all P-trend < 0.05). We also observed significant trends for the intakes of proanthocyanidin dimers (HR for the highest vs. the lowest quintile: 0.81; 95% CI: 0.71, 0.92; P-trend = 0.003) and trimers (HR: 0.91; 95% CI: 0.80, 1.04; P-trend = 0.07) but not for proanthocyanidins with a greater polymerization degree. Among the flavonol subclass, myricetin (HR: 0.77; 95% CI: 0.64, 0.93; P-trend = 0.001) was associated with a lower incidence of T2D. This large and heterogeneous European study showed inverse associations between all individual flavan-3-ol monomers, proanthocyanidins with a low polymerization degree, and the flavonol myricetin and incident T2D. These results suggest that individual flavonoids have different roles in the etiology of T2D. American Society for Nutrition 2014-03 2013-12-24 /pmc/articles/PMC3927546/ /pubmed/24368432 http://dx.doi.org/10.3945/jn.113.184945 Text en © 2014 American Society for Nutrition http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Nutritional Epidemiology Zamora-Ros, Raul Forouhi, Nita G. Sharp, Stephen J. González, Carlos A. Buijsse, Brian Guevara, Marcela van der Schouw, Yvonne T. Amiano, Pilar Boeing, Heiner Bredsdorff, Lea Fagherazzi, Guy Feskens, Edith J. Franks, Paul W. Grioni, Sara Katzke, Verena Key, Timothy J. Khaw, Kay-Tee Kühn, Tilman Masala, Giovanna Mattiello, Amalia Molina-Montes, Esther Nilsson, Peter M. Overvad, Kim Perquier, Florence Redondo, M. Luisa Ricceri, Fulvio Rolandsson, Olov Romieu, Isabelle Roswall, Nina Scalbert, Augustin Schulze, Matthias Slimani, Nadia Spijkerman, Annemieke M. W. Tjonneland, Anne Tormo, Maria Jose Touillaud, Marina Tumino, Rosario van der A, Daphne L. van Woudenbergh, Geertruida J. Langenberg, Claudia Riboli, Elio Wareham, Nicholas J. Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3) |
title | Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3) |
title_full | Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3) |
title_fullStr | Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3) |
title_full_unstemmed | Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3) |
title_short | Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3) |
title_sort | dietary intakes of individual flavanols and flavonols are inversely associated with incident type 2 diabetes in european populations(1)(2)(3) |
topic | Nutritional Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927546/ https://www.ncbi.nlm.nih.gov/pubmed/24368432 http://dx.doi.org/10.3945/jn.113.184945 |
work_keys_str_mv | AT zamorarosraul dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT forouhinitag dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT sharpstephenj dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT gonzalezcarlosa dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT buijssebrian dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT guevaramarcela dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT vanderschouwyvonnet dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT amianopilar dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT boeingheiner dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT bredsdorfflea dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT fagherazziguy dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT feskensedithj dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT frankspaulw dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT grionisara dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT katzkeverena dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT keytimothyj dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT khawkaytee dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT kuhntilman dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT masalagiovanna dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT mattielloamalia dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT molinamontesesther dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT nilssonpeterm dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT overvadkim dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT perquierflorence dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT redondomluisa dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT riccerifulvio dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT rolandssonolov dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT romieuisabelle dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT roswallnina dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT scalbertaugustin dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT schulzematthias dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT slimaninadia dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT spijkermanannemiekemw dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT tjonnelandanne dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT tormomariajose dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT touillaudmarina dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT tuminorosario dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT vanderadaphnel dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT vanwoudenberghgeertruidaj dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT langenbergclaudia dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT ribolielio dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 AT warehamnicholasj dietaryintakesofindividualflavanolsandflavonolsareinverselyassociatedwithincidenttype2diabetesineuropeanpopulations123 |