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Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3)

Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability and bioactivity. We aimed to examine the association between individual flav...

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Autores principales: Zamora-Ros, Raul, Forouhi, Nita G., Sharp, Stephen J., González, Carlos A., Buijsse, Brian, Guevara, Marcela, van der Schouw, Yvonne T., Amiano, Pilar, Boeing, Heiner, Bredsdorff, Lea, Fagherazzi, Guy, Feskens, Edith J., Franks, Paul W., Grioni, Sara, Katzke, Verena, Key, Timothy J., Khaw, Kay-Tee, Kühn, Tilman, Masala, Giovanna, Mattiello, Amalia, Molina-Montes, Esther, Nilsson, Peter M., Overvad, Kim, Perquier, Florence, Redondo, M. Luisa, Ricceri, Fulvio, Rolandsson, Olov, Romieu, Isabelle, Roswall, Nina, Scalbert, Augustin, Schulze, Matthias, Slimani, Nadia, Spijkerman, Annemieke M. W., Tjonneland, Anne, Tormo, Maria Jose, Touillaud, Marina, Tumino, Rosario, van der A, Daphne L., van Woudenbergh, Geertruida J., Langenberg, Claudia, Riboli, Elio, Wareham, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Nutrition 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927546/
https://www.ncbi.nlm.nih.gov/pubmed/24368432
http://dx.doi.org/10.3945/jn.113.184945
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author Zamora-Ros, Raul
Forouhi, Nita G.
Sharp, Stephen J.
González, Carlos A.
Buijsse, Brian
Guevara, Marcela
van der Schouw, Yvonne T.
Amiano, Pilar
Boeing, Heiner
Bredsdorff, Lea
Fagherazzi, Guy
Feskens, Edith J.
Franks, Paul W.
Grioni, Sara
Katzke, Verena
Key, Timothy J.
Khaw, Kay-Tee
Kühn, Tilman
Masala, Giovanna
Mattiello, Amalia
Molina-Montes, Esther
Nilsson, Peter M.
Overvad, Kim
Perquier, Florence
Redondo, M. Luisa
Ricceri, Fulvio
Rolandsson, Olov
Romieu, Isabelle
Roswall, Nina
Scalbert, Augustin
Schulze, Matthias
Slimani, Nadia
Spijkerman, Annemieke M. W.
Tjonneland, Anne
Tormo, Maria Jose
Touillaud, Marina
Tumino, Rosario
van der A, Daphne L.
van Woudenbergh, Geertruida J.
Langenberg, Claudia
Riboli, Elio
Wareham, Nicholas J.
author_facet Zamora-Ros, Raul
Forouhi, Nita G.
Sharp, Stephen J.
González, Carlos A.
Buijsse, Brian
Guevara, Marcela
van der Schouw, Yvonne T.
Amiano, Pilar
Boeing, Heiner
Bredsdorff, Lea
Fagherazzi, Guy
Feskens, Edith J.
Franks, Paul W.
Grioni, Sara
Katzke, Verena
Key, Timothy J.
Khaw, Kay-Tee
Kühn, Tilman
Masala, Giovanna
Mattiello, Amalia
Molina-Montes, Esther
Nilsson, Peter M.
Overvad, Kim
Perquier, Florence
Redondo, M. Luisa
Ricceri, Fulvio
Rolandsson, Olov
Romieu, Isabelle
Roswall, Nina
Scalbert, Augustin
Schulze, Matthias
Slimani, Nadia
Spijkerman, Annemieke M. W.
Tjonneland, Anne
Tormo, Maria Jose
Touillaud, Marina
Tumino, Rosario
van der A, Daphne L.
van Woudenbergh, Geertruida J.
Langenberg, Claudia
Riboli, Elio
Wareham, Nicholas J.
author_sort Zamora-Ros, Raul
collection PubMed
description Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability and bioactivity. We aimed to examine the association between individual flavanol and flavonol intakes and risk of developing T2D across European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC)–InterAct case-cohort study was conducted in 8 European countries across 26 study centers with 340,234 participants contributing 3.99 million person-years of follow-up, among whom 12,403 incident T2D cases were ascertained and a center-stratified subcohort of 16,154 individuals was defined. We estimated flavonoid intake at baseline from validated dietary questionnaires using a database developed from Phenol-Explorer and USDA databases. We used country-specific Prentice-weighted Cox regression models and random-effects meta-analysis methods to estimate HRs. Among the flavanol subclass, we observed significant inverse trends between intakes of all individual flavan-3-ol monomers and risk of T2D in multivariable models (all P-trend < 0.05). We also observed significant trends for the intakes of proanthocyanidin dimers (HR for the highest vs. the lowest quintile: 0.81; 95% CI: 0.71, 0.92; P-trend = 0.003) and trimers (HR: 0.91; 95% CI: 0.80, 1.04; P-trend = 0.07) but not for proanthocyanidins with a greater polymerization degree. Among the flavonol subclass, myricetin (HR: 0.77; 95% CI: 0.64, 0.93; P-trend = 0.001) was associated with a lower incidence of T2D. This large and heterogeneous European study showed inverse associations between all individual flavan-3-ol monomers, proanthocyanidins with a low polymerization degree, and the flavonol myricetin and incident T2D. These results suggest that individual flavonoids have different roles in the etiology of T2D.
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spelling pubmed-39275462014-03-04 Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3) Zamora-Ros, Raul Forouhi, Nita G. Sharp, Stephen J. González, Carlos A. Buijsse, Brian Guevara, Marcela van der Schouw, Yvonne T. Amiano, Pilar Boeing, Heiner Bredsdorff, Lea Fagherazzi, Guy Feskens, Edith J. Franks, Paul W. Grioni, Sara Katzke, Verena Key, Timothy J. Khaw, Kay-Tee Kühn, Tilman Masala, Giovanna Mattiello, Amalia Molina-Montes, Esther Nilsson, Peter M. Overvad, Kim Perquier, Florence Redondo, M. Luisa Ricceri, Fulvio Rolandsson, Olov Romieu, Isabelle Roswall, Nina Scalbert, Augustin Schulze, Matthias Slimani, Nadia Spijkerman, Annemieke M. W. Tjonneland, Anne Tormo, Maria Jose Touillaud, Marina Tumino, Rosario van der A, Daphne L. van Woudenbergh, Geertruida J. Langenberg, Claudia Riboli, Elio Wareham, Nicholas J. J Nutr Nutritional Epidemiology Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability and bioactivity. We aimed to examine the association between individual flavanol and flavonol intakes and risk of developing T2D across European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC)–InterAct case-cohort study was conducted in 8 European countries across 26 study centers with 340,234 participants contributing 3.99 million person-years of follow-up, among whom 12,403 incident T2D cases were ascertained and a center-stratified subcohort of 16,154 individuals was defined. We estimated flavonoid intake at baseline from validated dietary questionnaires using a database developed from Phenol-Explorer and USDA databases. We used country-specific Prentice-weighted Cox regression models and random-effects meta-analysis methods to estimate HRs. Among the flavanol subclass, we observed significant inverse trends between intakes of all individual flavan-3-ol monomers and risk of T2D in multivariable models (all P-trend < 0.05). We also observed significant trends for the intakes of proanthocyanidin dimers (HR for the highest vs. the lowest quintile: 0.81; 95% CI: 0.71, 0.92; P-trend = 0.003) and trimers (HR: 0.91; 95% CI: 0.80, 1.04; P-trend = 0.07) but not for proanthocyanidins with a greater polymerization degree. Among the flavonol subclass, myricetin (HR: 0.77; 95% CI: 0.64, 0.93; P-trend = 0.001) was associated with a lower incidence of T2D. This large and heterogeneous European study showed inverse associations between all individual flavan-3-ol monomers, proanthocyanidins with a low polymerization degree, and the flavonol myricetin and incident T2D. These results suggest that individual flavonoids have different roles in the etiology of T2D. American Society for Nutrition 2014-03 2013-12-24 /pmc/articles/PMC3927546/ /pubmed/24368432 http://dx.doi.org/10.3945/jn.113.184945 Text en © 2014 American Society for Nutrition http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Nutritional Epidemiology
Zamora-Ros, Raul
Forouhi, Nita G.
Sharp, Stephen J.
González, Carlos A.
Buijsse, Brian
Guevara, Marcela
van der Schouw, Yvonne T.
Amiano, Pilar
Boeing, Heiner
Bredsdorff, Lea
Fagherazzi, Guy
Feskens, Edith J.
Franks, Paul W.
Grioni, Sara
Katzke, Verena
Key, Timothy J.
Khaw, Kay-Tee
Kühn, Tilman
Masala, Giovanna
Mattiello, Amalia
Molina-Montes, Esther
Nilsson, Peter M.
Overvad, Kim
Perquier, Florence
Redondo, M. Luisa
Ricceri, Fulvio
Rolandsson, Olov
Romieu, Isabelle
Roswall, Nina
Scalbert, Augustin
Schulze, Matthias
Slimani, Nadia
Spijkerman, Annemieke M. W.
Tjonneland, Anne
Tormo, Maria Jose
Touillaud, Marina
Tumino, Rosario
van der A, Daphne L.
van Woudenbergh, Geertruida J.
Langenberg, Claudia
Riboli, Elio
Wareham, Nicholas J.
Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3)
title Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3)
title_full Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3)
title_fullStr Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3)
title_full_unstemmed Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3)
title_short Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations(1)(2)(3)
title_sort dietary intakes of individual flavanols and flavonols are inversely associated with incident type 2 diabetes in european populations(1)(2)(3)
topic Nutritional Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927546/
https://www.ncbi.nlm.nih.gov/pubmed/24368432
http://dx.doi.org/10.3945/jn.113.184945
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