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Parameters Associated with Significant Liver Histological Changes in Patients with Chronic Hepatitis B
This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927580/ https://www.ncbi.nlm.nih.gov/pubmed/24616815 http://dx.doi.org/10.1155/2014/913890 |
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author | Xiao, Li Xian, Jianchun Li, Yang Geng, Aiwen Yang, Xiuzhen Han, Libin Xu, Hongtao |
author_facet | Xiao, Li Xian, Jianchun Li, Yang Geng, Aiwen Yang, Xiuzhen Han, Libin Xu, Hongtao |
author_sort | Xiao, Li |
collection | PubMed |
description | This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P = 0.001, resp.). AST, WBC, and HBV DNA were significantly correlated with advanced fibrosis in normal ALT patients (P < 0.001, P = 0.041, and P = 0.012, resp.) and age, ALB, GLOB, PLT, and PT in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.). Age, AST, GGT, PLT, and PT were significantly associated with advanced fibrosis in HBeAg+ patients (P = 0.01, P = 0.016, P = 0.027, P = 0.016, and P = 0.009, resp.) and ALB, GLOB, WBC, PLT, and PT in HBeAg− patients (P < 0.001, P = 0.004, P = 0.005, P < 0.001, and P = 0.035, resp.). PLT was an excellent predictor for cirrhosis (P < 0.001 and AUROC = 0.805). ALT was not predictive of advanced fibrosis for patients with HBeAg+ or HBeAg− (P = 0.273 and P = 0.599, resp.). PLT was an excellent predictor for cirrhosis in CHB patients. Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB. |
format | Online Article Text |
id | pubmed-3927580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39275802014-03-10 Parameters Associated with Significant Liver Histological Changes in Patients with Chronic Hepatitis B Xiao, Li Xian, Jianchun Li, Yang Geng, Aiwen Yang, Xiuzhen Han, Libin Xu, Hongtao ISRN Gastroenterol Clinical Study This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P = 0.001, resp.). AST, WBC, and HBV DNA were significantly correlated with advanced fibrosis in normal ALT patients (P < 0.001, P = 0.041, and P = 0.012, resp.) and age, ALB, GLOB, PLT, and PT in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.). Age, AST, GGT, PLT, and PT were significantly associated with advanced fibrosis in HBeAg+ patients (P = 0.01, P = 0.016, P = 0.027, P = 0.016, and P = 0.009, resp.) and ALB, GLOB, WBC, PLT, and PT in HBeAg− patients (P < 0.001, P = 0.004, P = 0.005, P < 0.001, and P = 0.035, resp.). PLT was an excellent predictor for cirrhosis (P < 0.001 and AUROC = 0.805). ALT was not predictive of advanced fibrosis for patients with HBeAg+ or HBeAg− (P = 0.273 and P = 0.599, resp.). PLT was an excellent predictor for cirrhosis in CHB patients. Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB. Hindawi Publishing Corporation 2014-01-28 /pmc/articles/PMC3927580/ /pubmed/24616815 http://dx.doi.org/10.1155/2014/913890 Text en Copyright © 2014 Li Xiao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Xiao, Li Xian, Jianchun Li, Yang Geng, Aiwen Yang, Xiuzhen Han, Libin Xu, Hongtao Parameters Associated with Significant Liver Histological Changes in Patients with Chronic Hepatitis B |
title | Parameters Associated with Significant Liver Histological Changes in Patients with Chronic Hepatitis B |
title_full | Parameters Associated with Significant Liver Histological Changes in Patients with Chronic Hepatitis B |
title_fullStr | Parameters Associated with Significant Liver Histological Changes in Patients with Chronic Hepatitis B |
title_full_unstemmed | Parameters Associated with Significant Liver Histological Changes in Patients with Chronic Hepatitis B |
title_short | Parameters Associated with Significant Liver Histological Changes in Patients with Chronic Hepatitis B |
title_sort | parameters associated with significant liver histological changes in patients with chronic hepatitis b |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927580/ https://www.ncbi.nlm.nih.gov/pubmed/24616815 http://dx.doi.org/10.1155/2014/913890 |
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