Cargando…
The Evolution of Protein Structures and Structural Ensembles Under Functional Constraint
Protein sequence, structure, and function are inherently linked through evolution and population genetics. Our knowledge of protein structure comes from solved structures in the Protein Data Bank (PDB), our knowledge of sequence through sequences found in the NCBI sequence databases (http://www.ncbi...
Autores principales: | Siltberg-Liberles, Jessica, Grahnen, Johan A., Liberles, David A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927589/ https://www.ncbi.nlm.nih.gov/pubmed/24710290 http://dx.doi.org/10.3390/genes2040748 |
Ejemplares similares
-
Biophysical and structural considerations for protein sequence evolution
por: Grahnen, Johan A, et al.
Publicado: (2011) -
Paralog-Specific Patterns of Structural Disorder and Phosphorylation in the Vertebrate SH3–SH2–Tyrosine Kinase Protein Family
por: Dos Santos, Helena G., et al.
Publicado: (2016) -
Comparative Analysis of Structural Features in SLiMs from Eukaryotes, Bacteria, and Viruses with Importance for Host-Pathogen Interactions
por: Elkhaligy, Heidy, et al.
Publicado: (2022) -
Large-Scale Analyses of Site-Specific Evolutionary Rates across Eukaryote Proteomes Reveal Confounding Interactions between Intrinsic Disorder, Secondary Structure, and Functional Domains
por: Ahrens, Joseph B., et al.
Publicado: (2018) -
Avoiding Regions Symptomatic of Conformational and Functional Flexibility to Identify Antiviral Targets in Current and Future Coronaviruses
por: Rahaman, Jordon, et al.
Publicado: (2016)