Cargando…
Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion
Natural selection acts to maximize reproductive fitness. However, antagonism between life span and reproductive success frequently poses a dilemma pitting the cost of fecundity against longevity. Here, we show that natural populations of Drosophila melanogaster harbor a Hoppel transposon insertion v...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927810/ https://www.ncbi.nlm.nih.gov/pubmed/24519859 |
_version_ | 1782304180211286016 |
---|---|
author | Zhu, Chen-Tseh Chang, Chengyi Reenan, Robert A. Helfand, Stephen L. |
author_facet | Zhu, Chen-Tseh Chang, Chengyi Reenan, Robert A. Helfand, Stephen L. |
author_sort | Zhu, Chen-Tseh |
collection | PubMed |
description | Natural selection acts to maximize reproductive fitness. However, antagonism between life span and reproductive success frequently poses a dilemma pitting the cost of fecundity against longevity. Here, we show that natural populations of Drosophila melanogaster harbor a Hoppel transposon insertion variant in the longevity gene Indy (I'm not dead yet), which confers both increased reproduction and longevity through metabolic changes. Heterozygosity for this natural long-lived variant has been maintained in isolates despite long-term inbreeding under laboratory conditions and advantageously confers increased fecundity. DNA sequences of variant chromosome isolates show evidence of selective sweep acting on the advantageous allele, suggesting that natural selection acts to maintain this variant. The transposon insertion also regulates Indy expression level, which has experimentally been shown to affect life span and fecundity. Thus, in the wild, evolution reaffirms that the mechanism of heterozygote advantage has acted upon the Indy gene to assure increased reproductive fitness and, coincidentally, longer life span through regulatory transposon mutagenesis. |
format | Online Article Text |
id | pubmed-3927810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-39278102014-03-03 Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion Zhu, Chen-Tseh Chang, Chengyi Reenan, Robert A. Helfand, Stephen L. Aging (Albany NY) Research Paper Natural selection acts to maximize reproductive fitness. However, antagonism between life span and reproductive success frequently poses a dilemma pitting the cost of fecundity against longevity. Here, we show that natural populations of Drosophila melanogaster harbor a Hoppel transposon insertion variant in the longevity gene Indy (I'm not dead yet), which confers both increased reproduction and longevity through metabolic changes. Heterozygosity for this natural long-lived variant has been maintained in isolates despite long-term inbreeding under laboratory conditions and advantageously confers increased fecundity. DNA sequences of variant chromosome isolates show evidence of selective sweep acting on the advantageous allele, suggesting that natural selection acts to maintain this variant. The transposon insertion also regulates Indy expression level, which has experimentally been shown to affect life span and fecundity. Thus, in the wild, evolution reaffirms that the mechanism of heterozygote advantage has acted upon the Indy gene to assure increased reproductive fitness and, coincidentally, longer life span through regulatory transposon mutagenesis. Impact Journals LLC 2014-01-31 /pmc/articles/PMC3927810/ /pubmed/24519859 Text en Copyright: © 2014 Zhu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Research Paper Zhu, Chen-Tseh Chang, Chengyi Reenan, Robert A. Helfand, Stephen L. Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion |
title | Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion |
title_full | Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion |
title_fullStr | Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion |
title_full_unstemmed | Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion |
title_short | Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion |
title_sort | indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927810/ https://www.ncbi.nlm.nih.gov/pubmed/24519859 |
work_keys_str_mv | AT zhuchentseh indygenevariationinnaturalpopulationsconfersfitnessadvantageandlifespanextensionthroughtransposoninsertion AT changchengyi indygenevariationinnaturalpopulationsconfersfitnessadvantageandlifespanextensionthroughtransposoninsertion AT reenanroberta indygenevariationinnaturalpopulationsconfersfitnessadvantageandlifespanextensionthroughtransposoninsertion AT helfandstephenl indygenevariationinnaturalpopulationsconfersfitnessadvantageandlifespanextensionthroughtransposoninsertion |