Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks

WRN protein, defective in Werner syndrome (WS), a human segmental progeria, is a target of serine/threonine kinases involved in sensing DNA damage. DNA-PK phosphorylates WRN in response to DNA double strand breaks (DSBs). However, the main phosphorylation sites and functional importance of the phosp...

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Detalles Bibliográficos
Autores principales: Kusumoto-Matsuo, Rika, Ghosh, Deblina, Karmakar, Parimal, May, Alfred, Ramsden, Dale, Bohr, Vilhelm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927811/
https://www.ncbi.nlm.nih.gov/pubmed/24429382

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