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Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours

The Tasmanian Devil Facial Tumour Disease (DFTD) provides a unique opportunity to elucidate the long-term effects of natural and anthropogenic selection on cancer evolution. Since first observed in 1996, this transmissible cancer has caused local population declines by >90%. So far, four chromoso...

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Autores principales: Ujvari, Beata, Pearse, Anne-Maree, Swift, Kate, Hodson, Pamela, Hua, Bobby, Pyecroft, Stephen, Taylor, Robyn, Hamede, Rodrigo, Jones, Menna, Belov, Katherine, Madsen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927887/
https://www.ncbi.nlm.nih.gov/pubmed/24567746
http://dx.doi.org/10.1111/eva.12117
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author Ujvari, Beata
Pearse, Anne-Maree
Swift, Kate
Hodson, Pamela
Hua, Bobby
Pyecroft, Stephen
Taylor, Robyn
Hamede, Rodrigo
Jones, Menna
Belov, Katherine
Madsen, Thomas
author_facet Ujvari, Beata
Pearse, Anne-Maree
Swift, Kate
Hodson, Pamela
Hua, Bobby
Pyecroft, Stephen
Taylor, Robyn
Hamede, Rodrigo
Jones, Menna
Belov, Katherine
Madsen, Thomas
author_sort Ujvari, Beata
collection PubMed
description The Tasmanian Devil Facial Tumour Disease (DFTD) provides a unique opportunity to elucidate the long-term effects of natural and anthropogenic selection on cancer evolution. Since first observed in 1996, this transmissible cancer has caused local population declines by >90%. So far, four chromosomal DFTD variants (strains) have been described and karyotypic analyses of 253 tumours showed higher levels of tetraploidy in the oldest strain. We propose that increased ploidy in the oldest strain may have evolved in response to effects of genomic decay observed in asexually reproducing organisms. In this study, we focus on the evolutionary response of DFTD to a disease suppression trial. Tumours collected from devils subjected to the removal programme showed accelerated temporal evolution of tetraploidy compared with tumours from other populations where no increase in tetraploid tumours were observed. As ploidy significantly reduces tumour growth rate, we suggest that the disease suppression trial resulted in selection favouring slower growing tumours mediated by an increased level of tetraploidy. Our study reveals that DFTD has the capacity to rapidly respond to novel selective regimes and that disease eradication may result in novel tumour adaptations, which may further imperil the long-term survival of the world's largest carnivorous marsupial.
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spelling pubmed-39278872014-02-24 Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours Ujvari, Beata Pearse, Anne-Maree Swift, Kate Hodson, Pamela Hua, Bobby Pyecroft, Stephen Taylor, Robyn Hamede, Rodrigo Jones, Menna Belov, Katherine Madsen, Thomas Evol Appl Original Article The Tasmanian Devil Facial Tumour Disease (DFTD) provides a unique opportunity to elucidate the long-term effects of natural and anthropogenic selection on cancer evolution. Since first observed in 1996, this transmissible cancer has caused local population declines by >90%. So far, four chromosomal DFTD variants (strains) have been described and karyotypic analyses of 253 tumours showed higher levels of tetraploidy in the oldest strain. We propose that increased ploidy in the oldest strain may have evolved in response to effects of genomic decay observed in asexually reproducing organisms. In this study, we focus on the evolutionary response of DFTD to a disease suppression trial. Tumours collected from devils subjected to the removal programme showed accelerated temporal evolution of tetraploidy compared with tumours from other populations where no increase in tetraploid tumours were observed. As ploidy significantly reduces tumour growth rate, we suggest that the disease suppression trial resulted in selection favouring slower growing tumours mediated by an increased level of tetraploidy. Our study reveals that DFTD has the capacity to rapidly respond to novel selective regimes and that disease eradication may result in novel tumour adaptations, which may further imperil the long-term survival of the world's largest carnivorous marsupial. John Wiley & Sons Ltd 2014-02 2013-11-06 /pmc/articles/PMC3927887/ /pubmed/24567746 http://dx.doi.org/10.1111/eva.12117 Text en © 2013 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ujvari, Beata
Pearse, Anne-Maree
Swift, Kate
Hodson, Pamela
Hua, Bobby
Pyecroft, Stephen
Taylor, Robyn
Hamede, Rodrigo
Jones, Menna
Belov, Katherine
Madsen, Thomas
Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours
title Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours
title_full Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours
title_fullStr Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours
title_full_unstemmed Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours
title_short Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours
title_sort anthropogenic selection enhances cancer evolution in tasmanian devil tumours
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927887/
https://www.ncbi.nlm.nih.gov/pubmed/24567746
http://dx.doi.org/10.1111/eva.12117
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