Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells

Human cancers modeled in Genetically Engineered Mouse Models (GEMMs) can provide important mechanistic insights into the molecular basis of tumor development and enable testing of new intervention strategies. The inherent complexity of these models, with often multiple modified tumor suppressor gene...

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Detalles Bibliográficos
Autores principales: Huijbers, Ivo J, Bin Ali, Rahmen, Pritchard, Colin, Cozijnsen, Miranda, Kwon, Min-Chul, Proost, Natalie, Song, Ji-Ying, Vries, Hilda, Badhai, Jitendra, Sutherland, Kate, Krimpenfort, Paul, Michalak, Ewa M, Jonkers, Jos, Berns, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927956/
https://www.ncbi.nlm.nih.gov/pubmed/24401838
http://dx.doi.org/10.1002/emmm.201303297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927956/
https://www.ncbi.nlm.nih.gov/pubmed/24401838
http://dx.doi.org/10.1002/emmm.201303297

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