Pre-B Cell Receptor Signaling Induces Immunoglobulin κ Locus Accessibility by Functional Redistribution of Enhancer-Mediated Chromatin Interactions

During B cell development, the precursor B cell receptor (pre-BCR) checkpoint is thought to increase immunoglobulin κ light chain (Igκ) locus accessibility to the V(D)J recombinase. Accordingly, pre-B cells lacking the pre-BCR signaling molecules Btk or Slp65 showed reduced germline V(κ) transcripti...

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Detalles Bibliográficos
Autores principales: Stadhouders, Ralph, de Bruijn, Marjolein J. W., Rother, Magdalena B., Yuvaraj, Saravanan, de Almeida, Claudia Ribeiro, Kolovos, Petros, Van Zelm, Menno C., van Ijcken, Wilfred, Grosveld, Frank, Soler, Eric, Hendriks, Rudi W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928034/
https://www.ncbi.nlm.nih.gov/pubmed/24558349
http://dx.doi.org/10.1371/journal.pbio.1001791

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