A Novel Pathway Links Oxidative Stress to Loss of Insulin Growth Factor-2 (IGF2) Imprinting through NF-κB Activation

Genomic imprinting is the allele-specific expression of a gene based on parental origin. Loss of imprinting(LOI) of Insulin-like Growth Factor 2 (IGF2) during aging is important in tumorigenesis, yet the regulatory mechanisms driving this event are largely unknown. In this study oxidative stress, me...

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Detalles Bibliográficos
Autores principales: Yang, Bing, Wagner, Jennifer, Damaschke, Nathan, Yao, Tianyu, Wuerzberger-Davis, Shelly M., Lee, Moon-Hee, Svaren, John, Miyamoto, Shigeki, Jarrard, David F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928145/
https://www.ncbi.nlm.nih.gov/pubmed/24558376
http://dx.doi.org/10.1371/journal.pone.0088052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928145/
https://www.ncbi.nlm.nih.gov/pubmed/24558376
http://dx.doi.org/10.1371/journal.pone.0088052

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