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A Human Artificial Chromosome Recapitulates the Metabolism of Native Telomeres in Mammalian Cells

Telomeric and subtelomeric regions of human chromosomes largely consist of highly repetitive and redundant DNA sequences, resulting in a paucity of unique DNA sequences specific to individual telomeres. Accordingly, it is difficult to analyze telomere metabolism on a single-telomere basis. To circum...

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Detalles Bibliográficos
Autores principales:	Wakai, Michihito, Abe, Satoshi, Kazuki, Yasuhiro, Oshimura, Mitsuo, Ishikawa, Fuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928237/ https://www.ncbi.nlm.nih.gov/pubmed/24558398 http://dx.doi.org/10.1371/journal.pone.0088530

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