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Masking Level Differences – A Diffusion Tensor Imaging and Functional MRI Study

In our previous study we investigated Masking Level Differences (MLD) using functional Magnetic Resonance Imaging (fMRI), but were unable to confirm neural correlations for the MLD within the auditory cortex and inferior colliculus. Here we have duplicated conditions from our previous study, but hav...

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Detalles Bibliográficos
Autores principales: Wack, David S., Polak, Paul, Furuyama, Jon, Burkard, Robert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928251/
https://www.ncbi.nlm.nih.gov/pubmed/24558392
http://dx.doi.org/10.1371/journal.pone.0088466
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author Wack, David S.
Polak, Paul
Furuyama, Jon
Burkard, Robert F.
author_facet Wack, David S.
Polak, Paul
Furuyama, Jon
Burkard, Robert F.
author_sort Wack, David S.
collection PubMed
description In our previous study we investigated Masking Level Differences (MLD) using functional Magnetic Resonance Imaging (fMRI), but were unable to confirm neural correlations for the MLD within the auditory cortex and inferior colliculus. Here we have duplicated conditions from our previous study, but have included more participants and changed the study site to a new location with a newer scanner and presentation system. Additionally, Diffusion Tensor Imaging (DTI) is included to allow investigation of fiber tracts that may be involved with MLDs. Twenty participants were included and underwent audiometric testing and MRI scanning. The current study revealed regions of increased and decreased activity within the auditory cortex when comparing the combined noise and signal of the dichotic MLD stimuli (N0Sπ and NπS0) with N0S0. Furthermore, we found evidence of inferior colliculus involvement. Our DTI findings show strong correlations between DTI measures within the brainstem and signal detection threshold levels. Patterns of correlation when the signal was presented only to the right ear showed an extensive network in the left hemisphere; however, the opposite was not true for the signal presented only to the left ear. Our current study was able to confirm what we had previously hypothesized using fMRI, while extending our investigation of MLDs to include the characteristics of connecting neural pathways.
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spelling pubmed-39282512014-02-20 Masking Level Differences – A Diffusion Tensor Imaging and Functional MRI Study Wack, David S. Polak, Paul Furuyama, Jon Burkard, Robert F. PLoS One Research Article In our previous study we investigated Masking Level Differences (MLD) using functional Magnetic Resonance Imaging (fMRI), but were unable to confirm neural correlations for the MLD within the auditory cortex and inferior colliculus. Here we have duplicated conditions from our previous study, but have included more participants and changed the study site to a new location with a newer scanner and presentation system. Additionally, Diffusion Tensor Imaging (DTI) is included to allow investigation of fiber tracts that may be involved with MLDs. Twenty participants were included and underwent audiometric testing and MRI scanning. The current study revealed regions of increased and decreased activity within the auditory cortex when comparing the combined noise and signal of the dichotic MLD stimuli (N0Sπ and NπS0) with N0S0. Furthermore, we found evidence of inferior colliculus involvement. Our DTI findings show strong correlations between DTI measures within the brainstem and signal detection threshold levels. Patterns of correlation when the signal was presented only to the right ear showed an extensive network in the left hemisphere; however, the opposite was not true for the signal presented only to the left ear. Our current study was able to confirm what we had previously hypothesized using fMRI, while extending our investigation of MLDs to include the characteristics of connecting neural pathways. Public Library of Science 2014-02-18 /pmc/articles/PMC3928251/ /pubmed/24558392 http://dx.doi.org/10.1371/journal.pone.0088466 Text en © 2014 Wack et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wack, David S.
Polak, Paul
Furuyama, Jon
Burkard, Robert F.
Masking Level Differences – A Diffusion Tensor Imaging and Functional MRI Study
title Masking Level Differences – A Diffusion Tensor Imaging and Functional MRI Study
title_full Masking Level Differences – A Diffusion Tensor Imaging and Functional MRI Study
title_fullStr Masking Level Differences – A Diffusion Tensor Imaging and Functional MRI Study
title_full_unstemmed Masking Level Differences – A Diffusion Tensor Imaging and Functional MRI Study
title_short Masking Level Differences – A Diffusion Tensor Imaging and Functional MRI Study
title_sort masking level differences – a diffusion tensor imaging and functional mri study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928251/
https://www.ncbi.nlm.nih.gov/pubmed/24558392
http://dx.doi.org/10.1371/journal.pone.0088466
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