Association of Fas -1377 G/A Polymorphism with Susceptibility to Cancer

BACKGROUND: The relationship between Fas -1377 G/A polymorphism and cancer susceptibility has been implicated in accumulating data. However, the data presented inconsistent results. This study was devised to investigate the association of Fas -1377 G/A polymorphism and cancer susceptibility in a large number of participants. METHODS: The databases of PubMed, Embase, and Web of Science were searched and a total of 27 case-control studies including 13,355 cases and 16,078 controls were included in this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the fixed-effects model. Statistical analyses were performed by using Stata software. RESULTS: The results suggested that Fas -1377 G/A polymorphism was overall associated with cancer susceptibility (additive model: OR, 1.16, 95%CI = 1.06–1.27, P (heterogeneity) = 0.381; recessive model: OR, 1.19, 95%CI = 1.10–1.29, P (heterogeneity) = 0.137). In the subgroup analysis by cancer type, significantly increased risk was observed in breast cancer (additive model: OR, 1.24, 95%CI = 1.04–1.58, P (heterogeneity) = 0.614; recessive model: OR, 1.24, 95%CI = 1.02–1.51, P (heterogeneity) = 0.349) and lung cancer (recessive model: OR, 1.25, 95%CI = 1.04–1.49, P (heterogeneity) = 0.090). Similarly, elevated cancer risk associated with Fas -1377 G/A polymorphism was revealed in Asians. CONCLUSIONS: The combined results suggest that Fas -1377 G/A polymorphism might modulate cancer susceptibility in an Asian-specific manner.