Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M(1) and M(4) Subtypes of Muscarinic Acetylcholine Receptors

Xanomeline is an agonist endowed with functional preference for M(1)/M(4) muscarinic acetylcholine receptors. It also exhibits both reversible and wash-resistant binding to and activation of these receptors. So far the mechanisms of xanomeline selectivity remain unknown. To address this question we...

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Detalles Bibliográficos
Autores principales: Šantrůčková, Eva, Doležal, Vladimír, El-Fakahany, Esam E., Jakubík, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928307/
https://www.ncbi.nlm.nih.gov/pubmed/24558448
http://dx.doi.org/10.1371/journal.pone.0088910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928307/
https://www.ncbi.nlm.nih.gov/pubmed/24558448
http://dx.doi.org/10.1371/journal.pone.0088910

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