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p53-Independent Cell Cycle and Erythroid Differentiation Defects in Murine Embryonic Stem Cells Haploinsufficient for Diamond Blackfan Anemia-Proteins: RPS19 versus RPL5

Diamond Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome caused by ribosomal protein haploinsufficiency. DBA exhibits marked phenotypic variability, commonly presenting with erythroid hypoplasia, less consistently with non-erythroid features. The p53 pathway, activated by abort...

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Detalles Bibliográficos
Autores principales:	Singh, Sharon A., Goldberg, Tracie A., Henson, Adrianna L., Husain-Krautter, Sehba, Nihrane, Abdallah, Blanc, Lionel, Ellis, Steven R., Lipton, Jeffrey M., Liu, Johnson M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928369/ https://www.ncbi.nlm.nih.gov/pubmed/24558476 http://dx.doi.org/10.1371/journal.pone.0089098

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