GLI1 upregulates C-JUN through a specific 130-kDa isoform

The Hedgehog pathway is molecularly linked to increased resistance to cisplatin and increased repair of platinum-DNA damage, through C-JUN. GLI1, which has five known isoforms, is a positive transcriptional regulator in Hedgehog. Southwestern blot assay, EMSA and ChIP assays indicate that only one o...

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Autores principales: AMABLE, LAUREN, GAVIN, ELAINE, KUDO, KENJI, MENG, ERHONG, ROCCONI, RODNEY P., SHEVDE, LALITA A., REED, EDDIE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928471/
https://www.ncbi.nlm.nih.gov/pubmed/24366538
http://dx.doi.org/10.3892/ijo.2013.2222
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author AMABLE, LAUREN
GAVIN, ELAINE
KUDO, KENJI
MENG, ERHONG
ROCCONI, RODNEY P.
SHEVDE, LALITA A.
REED, EDDIE
author_facet AMABLE, LAUREN
GAVIN, ELAINE
KUDO, KENJI
MENG, ERHONG
ROCCONI, RODNEY P.
SHEVDE, LALITA A.
REED, EDDIE
author_sort AMABLE, LAUREN
collection PubMed
description The Hedgehog pathway is molecularly linked to increased resistance to cisplatin and increased repair of platinum-DNA damage, through C-JUN. GLI1, which has five known isoforms, is a positive transcriptional regulator in Hedgehog. Southwestern blot assay, EMSA and ChIP assays indicate that only one of five isoforms of GLI1 may be responsible for the Hedgehog link with C-JUN and thus, increased platinum-DNA adduct repair. Cancer tissues express this 130-kDa isoform at levels 6-fold higher than non-malignant tissues; and this isoform exists in abundance in six of seven ovarian cancer cell lines examined.
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spelling pubmed-39284712014-02-24 GLI1 upregulates C-JUN through a specific 130-kDa isoform AMABLE, LAUREN GAVIN, ELAINE KUDO, KENJI MENG, ERHONG ROCCONI, RODNEY P. SHEVDE, LALITA A. REED, EDDIE Int J Oncol Articles The Hedgehog pathway is molecularly linked to increased resistance to cisplatin and increased repair of platinum-DNA damage, through C-JUN. GLI1, which has five known isoforms, is a positive transcriptional regulator in Hedgehog. Southwestern blot assay, EMSA and ChIP assays indicate that only one of five isoforms of GLI1 may be responsible for the Hedgehog link with C-JUN and thus, increased platinum-DNA adduct repair. Cancer tissues express this 130-kDa isoform at levels 6-fold higher than non-malignant tissues; and this isoform exists in abundance in six of seven ovarian cancer cell lines examined. D.A. Spandidos 2013-12-20 /pmc/articles/PMC3928471/ /pubmed/24366538 http://dx.doi.org/10.3892/ijo.2013.2222 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
AMABLE, LAUREN
GAVIN, ELAINE
KUDO, KENJI
MENG, ERHONG
ROCCONI, RODNEY P.
SHEVDE, LALITA A.
REED, EDDIE
GLI1 upregulates C-JUN through a specific 130-kDa isoform
title GLI1 upregulates C-JUN through a specific 130-kDa isoform
title_full GLI1 upregulates C-JUN through a specific 130-kDa isoform
title_fullStr GLI1 upregulates C-JUN through a specific 130-kDa isoform
title_full_unstemmed GLI1 upregulates C-JUN through a specific 130-kDa isoform
title_short GLI1 upregulates C-JUN through a specific 130-kDa isoform
title_sort gli1 upregulates c-jun through a specific 130-kda isoform
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928471/
https://www.ncbi.nlm.nih.gov/pubmed/24366538
http://dx.doi.org/10.3892/ijo.2013.2222
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