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GLI1 upregulates C-JUN through a specific 130-kDa isoform

The Hedgehog pathway is molecularly linked to increased resistance to cisplatin and increased repair of platinum-DNA damage, through C-JUN. GLI1, which has five known isoforms, is a positive transcriptional regulator in Hedgehog. Southwestern blot assay, EMSA and ChIP assays indicate that only one o...

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Detalles Bibliográficos
Autores principales:	AMABLE, LAUREN, GAVIN, ELAINE, KUDO, KENJI, MENG, ERHONG, ROCCONI, RODNEY P., SHEVDE, LALITA A., REED, EDDIE
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928471/ https://www.ncbi.nlm.nih.gov/pubmed/24366538 http://dx.doi.org/10.3892/ijo.2013.2222

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