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Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

[Image: see text] The molecular mechanisms by which different proteins assemble into highly ordered fibrillar deposits and cause disease remain topics of debate. Human amylin (also known as islet amyloid polypeptide/hIAPP) is found in vivo as amyloid deposits in the pancreatic islets of sufferers of...

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Detalles Bibliográficos
Autores principales:	Young, Lydia M., Cao, Ping, Raleigh, Daniel P., Ashcroft, Alison E., Radford, Sheena E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928500/ https://www.ncbi.nlm.nih.gov/pubmed/24372466 http://dx.doi.org/10.1021/ja406831n

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