Cargando…

Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system

HIV-associated neurocognitive disorder (HAND), characterized by a wide spectrum of behavioral, cognitive, and motor dysfunctions, continues to affect approximately 50 % of HIV(+) patients despite the success of combination antiretroviral drug therapy (cART) in the periphery. Of note, potential toxic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akay, Cagla, Cooper, Michael, Odeleye, Akinleye, Jensen, Brigid K., White, Michael G., Vassoler, Fair, Gannon, Patrick J., Mankowski, Joseph, Dorsey, Jamie L., Buch, Alison M., Cross, Stephanie A., Cook, Denise R., Peña, Michelle-Marie, Andersen, Emily S., Christofidou-Solomidou, Melpo, Lindl, Kathryn A., Zink, M. Christine, Clements, Janice, Pierce, R. Christopher, Kolson, Dennis L., Jordan-Sciutto, Kelly L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928514/ https://www.ncbi.nlm.nih.gov/pubmed/24420448 http://dx.doi.org/10.1007/s13365-013-0227-1

Ejemplares similares

Oxidative Stress and Space Biology: An Organ-Based Approach
por: Goodwin, Thomas J., et al.
Publicado: (2018)

Editorial to the Special Issue: “Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment”
por: Goodwin, Thomas J., et al.
Publicado: (2022)

HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities
por: Lindl, Kathryn A., et al.
Publicado: (2010)

Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation
por: Rom, Slava, et al.
Publicado: (2018)

Activation status of integrated stress response pathways in neurones and astrocytes of HIV‐associated neurocognitive disorders (HAND) cortex
por: Akay, C., et al.
Publicado: (2012)

Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605)
por: Pietrofesa, Ralph A., et al.
Publicado: (2016)

Synthetic Secoisolariciresinol Diglucoside Attenuates Established Pain, Oxidative Stress and Neuroinflammation in a Rodent Model of Painful Radiculopathy
por: Kartha, Sonia, et al.
Publicado: (2020)

The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage
por: Velalopoulou, Anastasia, et al.
Publicado: (2015)

Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines
por: Chikara, Shireen, et al.
Publicado: (2017)

Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection
por: Mishra, Om P., et al.
Publicado: (2016)

Late Inflammation Induced by Asbestiform Fibers in Mice Is Ameliorated by a Small Molecule Synthetic Lignan
por: Badger, Reagan, et al.
Publicado: (2021)

Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study
por: Turowski, Jason B, et al.
Publicado: (2015)

Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner
por: Pietrofesa, Ralph A., et al.
Publicado: (2018)

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells
por: Pietrofesa, Ralph A., et al.
Publicado: (2022)

The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages
por: Pietrofesa, Ralph A., et al.
Publicado: (2017)

Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes
por: Dukes, Floyd, et al.
Publicado: (2012)

Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice
por: Pietrofesa, Ralph A., et al.
Publicado: (2016)

LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks
por: Chatterjee, Shampa, et al.
Publicado: (2019)

Epigenetic Inheritance of a Cocaine Resistance Phenotype
por: Vassoler, Fair M., et al.
Publicado: (2012)

Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel
por: Pietrofesa, Ralph A., et al.
Publicado: (2016)

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage
por: Velalopoulou, Anastasia, et al.
Publicado: (2017)

Assessment of a Small Molecule Synthetic Lignan in Enhancing Oxidative Balance and Decreasing Lipid Accumulation in Human Retinal Pigment Epithelia
por: Dhingra, Anuradha, et al.
Publicado: (2021)

Anti-Inflammatory Effect of Targeted Delivery of SOD to Endothelium: Mechanism, Synergism with NO Donors and Protective Effects In Vitro and In Vivo
por: Shuvaev, Vladimir V., et al.
Publicado: (2013)

Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice
por: Christofidou-Solomidou, Melpo, et al.
Publicado: (2011)

Radiation mitigating properties of the lignan component in flaxseed
por: Pietrofesa, Ralph, et al.
Publicado: (2013)

Dietary Flaxseed in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation
por: Berman, Abigail T, et al.
Publicado: (2013)

More Than Two HANDs to Tango
por: Kolson, Dennis, et al.
Publicado: (2013)

Copper Oxide Nanoparticle-Induced Acute Inflammatory Response and Injury in Murine Lung Is Ameliorated by Synthetic Secoisolariciresinol Diglucoside (LGM2605)
por: Pietrofesa, Ralph A., et al.
Publicado: (2021)

Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir
por: Avalos, Claudia R., et al.
Publicado: (2017)

Intergenerational effects of preconception opioids on glucose homeostasis and hepatic transcription in adult male rats
por: Toorie, Anika M., et al.
Publicado: (2022)

Early Emergence and Selection of a SIV-LTR C/EBP Site Variant in SIV-Infected Macaques That Increases Virus Infectivity
por: Ravimohan, Shruthi, et al.
Publicado: (2012)

Correction: Early Emergence and Selection of a SIV-LTR C/EBP Site Variant in SIV-Infected Macaques That Increases Virus Infectivity
por: Ravimohan, Shruthi, et al.
Publicado: (2013)

When do models of NeuroAIDS faithfully imitate “the real thing”?
por: Gelman, Benjamin B., et al.
Publicado: (2017)

Developments in Neuroprotection for HIV-Associated Neurocognitive Disorders (HAND)
por: Kolson, Dennis L.
Publicado: (2022)

Coordinated Regulation of SIV Replication and Immune Responses in the CNS
por: Witwer, Kenneth W., et al.
Publicado: (2009)

Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques
por: Avalos, Claudia R., et al.
Publicado: (2016)

Adult Neurogenesis in the Female Mouse Hypothalamus: Estradiol and High-Fat Diet Alter the Generation of Newborn Neurons Expressing Estrogen Receptor α
por: Bless, Elizabeth P., et al.
Publicado: (2016)

Heme Oxygenase-1 Dysregulation in the Brain: Implications for HIV-Associated Neurocognitive Disorders
por: Ambegaokar, Surendra S, et al.
Publicado: (2014)

PKR-like ER kinase (PERK) Haplotypes Are Associated with Depressive Symptoms in People with HIV
por: Haddadi, S, et al.
Publicado: (2023)

Induction of Innate Immune Responses by SIV In Vivo and In Vitro: Differential Expression and Function of RIG-I and MDA5
por: Co, Juliene G., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_3bebvvq3678rd7cdps28mi0gm2