TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1)

The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell anti-viral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in approximately 20% of human glioblastomas raised the possibility that this...

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Autores principales: Liu, Yuhui, Raheja, Radhika, Yeh, Nancy, Ciznadija, Daniel, Pedraza, Alicia M., Ozawa, Tatsuya, Hukkelhoven, Ellen, Erdjument-Bromage, Hediye, Tempst, Paul, Gauthier, Nicholas Paul, Brennan, Cameron, Holland, Eric C., Koff, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928554/
https://www.ncbi.nlm.nih.gov/pubmed/23318451
http://dx.doi.org/10.1038/onc.2012.596
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author Liu, Yuhui
Raheja, Radhika
Yeh, Nancy
Ciznadija, Daniel
Pedraza, Alicia M.
Ozawa, Tatsuya
Hukkelhoven, Ellen
Erdjument-Bromage, Hediye
Tempst, Paul
Gauthier, Nicholas Paul
Brennan, Cameron
Holland, Eric C.
Koff, Andrew
author_facet Liu, Yuhui
Raheja, Radhika
Yeh, Nancy
Ciznadija, Daniel
Pedraza, Alicia M.
Ozawa, Tatsuya
Hukkelhoven, Ellen
Erdjument-Bromage, Hediye
Tempst, Paul
Gauthier, Nicholas Paul
Brennan, Cameron
Holland, Eric C.
Koff, Andrew
author_sort Liu, Yuhui
collection PubMed
description The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell anti-viral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in approximately 20% of human glioblastomas raised the possibility that this NHL containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of PDGF-induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21(WAF1/CIP1). Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it can block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4.
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spelling pubmed-39285542014-07-16 TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1) Liu, Yuhui Raheja, Radhika Yeh, Nancy Ciznadija, Daniel Pedraza, Alicia M. Ozawa, Tatsuya Hukkelhoven, Ellen Erdjument-Bromage, Hediye Tempst, Paul Gauthier, Nicholas Paul Brennan, Cameron Holland, Eric C. Koff, Andrew Oncogene Article The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell anti-viral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in approximately 20% of human glioblastomas raised the possibility that this NHL containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of PDGF-induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21(WAF1/CIP1). Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it can block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4. 2013-01-14 2014-01-16 /pmc/articles/PMC3928554/ /pubmed/23318451 http://dx.doi.org/10.1038/onc.2012.596 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Liu, Yuhui
Raheja, Radhika
Yeh, Nancy
Ciznadija, Daniel
Pedraza, Alicia M.
Ozawa, Tatsuya
Hukkelhoven, Ellen
Erdjument-Bromage, Hediye
Tempst, Paul
Gauthier, Nicholas Paul
Brennan, Cameron
Holland, Eric C.
Koff, Andrew
TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1)
title TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1)
title_full TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1)
title_fullStr TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1)
title_full_unstemmed TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1)
title_short TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1)
title_sort trim3, a tumor suppressor linked to regulation of p21(waf1/cip1)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928554/
https://www.ncbi.nlm.nih.gov/pubmed/23318451
http://dx.doi.org/10.1038/onc.2012.596
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