Cargando…

High number of diarrhoeal co-infections in travellers to Benin, West Africa

BACKGROUND: Travellers’ diarrhoea (TD) is the most frequent health problem among travellers to the tropics. Using routine techniques, the aetiology mostly remains unresolved, whereas modern molecular methods enable reducing the number of equivocal cases considerably. While many studies address the a...

Descripción completa

Detalles Bibliográficos
Autores principales: Lääveri, Tinja, Pakkanen, Sari H, Antikainen, Jenni, Riutta, Jukka, Mero, Sointu, Kirveskari, Juha, Kantele, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928613/
https://www.ncbi.nlm.nih.gov/pubmed/24521079
http://dx.doi.org/10.1186/1471-2334-14-81
_version_ 1782304292959420416
author Lääveri, Tinja
Pakkanen, Sari H
Antikainen, Jenni
Riutta, Jukka
Mero, Sointu
Kirveskari, Juha
Kantele, Anu
author_facet Lääveri, Tinja
Pakkanen, Sari H
Antikainen, Jenni
Riutta, Jukka
Mero, Sointu
Kirveskari, Juha
Kantele, Anu
author_sort Lääveri, Tinja
collection PubMed
description BACKGROUND: Travellers’ diarrhoea (TD) is the most frequent health problem among travellers to the tropics. Using routine techniques, the aetiology mostly remains unresolved, whereas modern molecular methods enable reducing the number of equivocal cases considerably. While many studies address the aetiology of TD in Asian, Central American and North African tourist resorts, only few focus on Western Africa. METHODS: Stool samples from 45 travellers travelling in Benin, West Africa, were analyzed by a new multiplex qPCR assay for Salmonella, Yersinia, Campylobacter, Vibrio cholerae, Shigella or enteroinvasive (EIEC), enterohaemorrhagic (EHEC), enterotoxigenic (ETEC), enteroaggregative (EAEC), and enteropathogenic Escherichia coli (EPEC). RESULTS: All 18 pre-travel samples proved negative for bacterial pathogens. Of the 39/45 (87%) travellers having had TD, EPEC was detected in post-travel samples in 30 (77%) cases, EAEC in 23 (59%), ETEC in 22 (56%), Shigella or EIEC in 7 (18%), EHEC in two (5%), and Salmonella in one (3%). In 31(79%) of the TD cases two or more bacterial pathogens were identified. Two (8%) samples remained negative: both patients had taken antimicrobials for TD. CONCLUSIONS: EPEC, EAEC and ETEC were the most common findings. 79% of the cases had a co-infection. As modern diagnostics reveals in most patients a multitude of pathogens, the role of each pathogen should be re-evaluated.
format Online
Article
Text
id pubmed-3928613
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-39286132014-02-20 High number of diarrhoeal co-infections in travellers to Benin, West Africa Lääveri, Tinja Pakkanen, Sari H Antikainen, Jenni Riutta, Jukka Mero, Sointu Kirveskari, Juha Kantele, Anu BMC Infect Dis Research Article BACKGROUND: Travellers’ diarrhoea (TD) is the most frequent health problem among travellers to the tropics. Using routine techniques, the aetiology mostly remains unresolved, whereas modern molecular methods enable reducing the number of equivocal cases considerably. While many studies address the aetiology of TD in Asian, Central American and North African tourist resorts, only few focus on Western Africa. METHODS: Stool samples from 45 travellers travelling in Benin, West Africa, were analyzed by a new multiplex qPCR assay for Salmonella, Yersinia, Campylobacter, Vibrio cholerae, Shigella or enteroinvasive (EIEC), enterohaemorrhagic (EHEC), enterotoxigenic (ETEC), enteroaggregative (EAEC), and enteropathogenic Escherichia coli (EPEC). RESULTS: All 18 pre-travel samples proved negative for bacterial pathogens. Of the 39/45 (87%) travellers having had TD, EPEC was detected in post-travel samples in 30 (77%) cases, EAEC in 23 (59%), ETEC in 22 (56%), Shigella or EIEC in 7 (18%), EHEC in two (5%), and Salmonella in one (3%). In 31(79%) of the TD cases two or more bacterial pathogens were identified. Two (8%) samples remained negative: both patients had taken antimicrobials for TD. CONCLUSIONS: EPEC, EAEC and ETEC were the most common findings. 79% of the cases had a co-infection. As modern diagnostics reveals in most patients a multitude of pathogens, the role of each pathogen should be re-evaluated. BioMed Central 2014-02-12 /pmc/articles/PMC3928613/ /pubmed/24521079 http://dx.doi.org/10.1186/1471-2334-14-81 Text en Copyright © 2014 Lääveri et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Lääveri, Tinja
Pakkanen, Sari H
Antikainen, Jenni
Riutta, Jukka
Mero, Sointu
Kirveskari, Juha
Kantele, Anu
High number of diarrhoeal co-infections in travellers to Benin, West Africa
title High number of diarrhoeal co-infections in travellers to Benin, West Africa
title_full High number of diarrhoeal co-infections in travellers to Benin, West Africa
title_fullStr High number of diarrhoeal co-infections in travellers to Benin, West Africa
title_full_unstemmed High number of diarrhoeal co-infections in travellers to Benin, West Africa
title_short High number of diarrhoeal co-infections in travellers to Benin, West Africa
title_sort high number of diarrhoeal co-infections in travellers to benin, west africa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928613/
https://www.ncbi.nlm.nih.gov/pubmed/24521079
http://dx.doi.org/10.1186/1471-2334-14-81
work_keys_str_mv AT laaveritinja highnumberofdiarrhoealcoinfectionsintravellerstobeninwestafrica
AT pakkanensarih highnumberofdiarrhoealcoinfectionsintravellerstobeninwestafrica
AT antikainenjenni highnumberofdiarrhoealcoinfectionsintravellerstobeninwestafrica
AT riuttajukka highnumberofdiarrhoealcoinfectionsintravellerstobeninwestafrica
AT merosointu highnumberofdiarrhoealcoinfectionsintravellerstobeninwestafrica
AT kirveskarijuha highnumberofdiarrhoealcoinfectionsintravellerstobeninwestafrica
AT kanteleanu highnumberofdiarrhoealcoinfectionsintravellerstobeninwestafrica