Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α

BACKGROUND: Endoplasmic reticulum stress, caused by the presence of misfolded proteins, activates the stress sensor inositol-requiring enzyme 1α (IRE1α). The resulting increase in IRE1α RNase activity causes sequence-specific cleavage of X-box binding protein 1 (XBP1) mRNA, resulting in upregulation...

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Detalles Bibliográficos
Autores principales: Itzhak, Daniel, Bright, Michael, McAndrew, Peter, Mirza, Amin, Newbatt, Yvette, Strover, Jade, Widya, Marcella, Thompson, Andrew, Morgan, Gareth, Collins, Ian, Davies, Faith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928614/
https://www.ncbi.nlm.nih.gov/pubmed/24524643
http://dx.doi.org/10.1186/1471-2091-15-3

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