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Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases
Thermoreversible gel of meloxicam, efficient for the treatment of joint diseases, was aimed to prepare for night application available for chronotherapy in this study. Poloxamer 407 and 188 polymers were used at 20-30% w/w as a vehicle in combination with different additives (polyvinylmethylether ma...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928734/ https://www.ncbi.nlm.nih.gov/pubmed/24591745 |
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author | Inal, O. Yapar, E. Alğin |
author_facet | Inal, O. Yapar, E. Alğin |
author_sort | Inal, O. |
collection | PubMed |
description | Thermoreversible gel of meloxicam, efficient for the treatment of joint diseases, was aimed to prepare for night application available for chronotherapy in this study. Poloxamer 407 and 188 polymers were used at 20-30% w/w as a vehicle in combination with different additives (polyvinylmethylether maleic anhydride copolymer, hydroxypropyl methylcellulose, polyethylene glycol 400, dimethyl sulfoxide, sodium chloride). Characterisation of prepared gels was evaluated by viscosity and texture analysis, and the effect of formulation variables on the gel formulations were evaluated by in vitro drug release and erosion studies. Between the investigated gel bases, Poloxamer 407-hydroxypropyl methylcellulose gel was found to be ideal due to its gel strength (1.560±0.0135 N), viscosity (312.3±2.06 cP) and release characteristics. These promising results could be encouraging for further studies to make it an alternative to commercial dosage forms. |
format | Online Article Text |
id | pubmed-3928734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39287342014-03-03 Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases Inal, O. Yapar, E. Alğin Indian J Pharm Sci Research Paper Thermoreversible gel of meloxicam, efficient for the treatment of joint diseases, was aimed to prepare for night application available for chronotherapy in this study. Poloxamer 407 and 188 polymers were used at 20-30% w/w as a vehicle in combination with different additives (polyvinylmethylether maleic anhydride copolymer, hydroxypropyl methylcellulose, polyethylene glycol 400, dimethyl sulfoxide, sodium chloride). Characterisation of prepared gels was evaluated by viscosity and texture analysis, and the effect of formulation variables on the gel formulations were evaluated by in vitro drug release and erosion studies. Between the investigated gel bases, Poloxamer 407-hydroxypropyl methylcellulose gel was found to be ideal due to its gel strength (1.560±0.0135 N), viscosity (312.3±2.06 cP) and release characteristics. These promising results could be encouraging for further studies to make it an alternative to commercial dosage forms. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3928734/ /pubmed/24591745 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Inal, O. Yapar, E. Alğin Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases |
title | Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases |
title_full | Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases |
title_fullStr | Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases |
title_full_unstemmed | Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases |
title_short | Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases |
title_sort | effect of mechanical properties on the release of meloxicam from poloxamer gel bases |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928734/ https://www.ncbi.nlm.nih.gov/pubmed/24591745 |
work_keys_str_mv | AT inalo effectofmechanicalpropertiesonthereleaseofmeloxicamfrompoloxamergelbases AT yaparealgin effectofmechanicalpropertiesonthereleaseofmeloxicamfrompoloxamergelbases |