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Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases

Thermoreversible gel of meloxicam, efficient for the treatment of joint diseases, was aimed to prepare for night application available for chronotherapy in this study. Poloxamer 407 and 188 polymers were used at 20-30% w/w as a vehicle in combination with different additives (polyvinylmethylether ma...

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Detalles Bibliográficos
Autores principales: Inal, O., Yapar, E. Alğin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928734/
https://www.ncbi.nlm.nih.gov/pubmed/24591745
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author Inal, O.
Yapar, E. Alğin
author_facet Inal, O.
Yapar, E. Alğin
author_sort Inal, O.
collection PubMed
description Thermoreversible gel of meloxicam, efficient for the treatment of joint diseases, was aimed to prepare for night application available for chronotherapy in this study. Poloxamer 407 and 188 polymers were used at 20-30% w/w as a vehicle in combination with different additives (polyvinylmethylether maleic anhydride copolymer, hydroxypropyl methylcellulose, polyethylene glycol 400, dimethyl sulfoxide, sodium chloride). Characterisation of prepared gels was evaluated by viscosity and texture analysis, and the effect of formulation variables on the gel formulations were evaluated by in vitro drug release and erosion studies. Between the investigated gel bases, Poloxamer 407-hydroxypropyl methylcellulose gel was found to be ideal due to its gel strength (1.560±0.0135 N), viscosity (312.3±2.06 cP) and release characteristics. These promising results could be encouraging for further studies to make it an alternative to commercial dosage forms.
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spelling pubmed-39287342014-03-03 Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases Inal, O. Yapar, E. Alğin Indian J Pharm Sci Research Paper Thermoreversible gel of meloxicam, efficient for the treatment of joint diseases, was aimed to prepare for night application available for chronotherapy in this study. Poloxamer 407 and 188 polymers were used at 20-30% w/w as a vehicle in combination with different additives (polyvinylmethylether maleic anhydride copolymer, hydroxypropyl methylcellulose, polyethylene glycol 400, dimethyl sulfoxide, sodium chloride). Characterisation of prepared gels was evaluated by viscosity and texture analysis, and the effect of formulation variables on the gel formulations were evaluated by in vitro drug release and erosion studies. Between the investigated gel bases, Poloxamer 407-hydroxypropyl methylcellulose gel was found to be ideal due to its gel strength (1.560±0.0135 N), viscosity (312.3±2.06 cP) and release characteristics. These promising results could be encouraging for further studies to make it an alternative to commercial dosage forms. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3928734/ /pubmed/24591745 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Inal, O.
Yapar, E. Alğin
Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases
title Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases
title_full Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases
title_fullStr Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases
title_full_unstemmed Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases
title_short Effect of Mechanical Properties on the Release of Meloxicam from Poloxamer Gel Bases
title_sort effect of mechanical properties on the release of meloxicam from poloxamer gel bases
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928734/
https://www.ncbi.nlm.nih.gov/pubmed/24591745
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