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Motor-related brain activity during action observation: a neural substrate for electrocorticographic brain-computer interfaces after spinal cord injury

After spinal cord injury (SCI), motor commands from the brain are unable to reach peripheral nerves and muscles below the level of the lesion. Action observation (AO), in which a person observes someone else performing an action, has been used to augment traditional rehabilitation paradigms. Similar...

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Autores principales: Collinger, Jennifer L., Vinjamuri, Ramana, Degenhart, Alan D., Weber, Douglas J., Sudre, Gustavo P., Boninger, Michael L., Tyler-Kabara, Elizabeth C., Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928793/
https://www.ncbi.nlm.nih.gov/pubmed/24600359
http://dx.doi.org/10.3389/fnint.2014.00017
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author Collinger, Jennifer L.
Vinjamuri, Ramana
Degenhart, Alan D.
Weber, Douglas J.
Sudre, Gustavo P.
Boninger, Michael L.
Tyler-Kabara, Elizabeth C.
Wang, Wei
author_facet Collinger, Jennifer L.
Vinjamuri, Ramana
Degenhart, Alan D.
Weber, Douglas J.
Sudre, Gustavo P.
Boninger, Michael L.
Tyler-Kabara, Elizabeth C.
Wang, Wei
author_sort Collinger, Jennifer L.
collection PubMed
description After spinal cord injury (SCI), motor commands from the brain are unable to reach peripheral nerves and muscles below the level of the lesion. Action observation (AO), in which a person observes someone else performing an action, has been used to augment traditional rehabilitation paradigms. Similarly, AO can be used to derive the relationship between brain activity and movement kinematics for a motor-based brain-computer interface (BCI) even when the user cannot generate overt movements. BCIs use brain signals to control external devices to replace functions that have been lost due to SCI or other motor impairment. Previous studies have reported congruent motor cortical activity during observed and overt movements using magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI). Recent single-unit studies using intracortical microelectrodes also demonstrated that a large number of motor cortical neurons had similar firing rate patterns between overt and observed movements. Given the increasing interest in electrocorticography (ECoG)-based BCIs, our goal was to identify whether action observation-related cortical activity could be recorded using ECoG during grasping tasks. Specifically, we aimed to identify congruent neural activity during observed and executed movements in both the sensorimotor rhythm (10–40 Hz) and the high-gamma band (65–115 Hz) which contains significant movement-related information. We observed significant motor-related high-gamma band activity during AO in both able-bodied individuals and one participant with a complete C4 SCI. Furthermore, in able-bodied participants, both the low and high frequency bands demonstrated congruent activity between action execution and observation. Our results suggest that AO could be an effective and critical procedure for deriving the mapping from ECoG signals to intended movement for an ECoG-based BCI system for individuals with paralysis.
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spelling pubmed-39287932014-03-05 Motor-related brain activity during action observation: a neural substrate for electrocorticographic brain-computer interfaces after spinal cord injury Collinger, Jennifer L. Vinjamuri, Ramana Degenhart, Alan D. Weber, Douglas J. Sudre, Gustavo P. Boninger, Michael L. Tyler-Kabara, Elizabeth C. Wang, Wei Front Integr Neurosci Neuroscience After spinal cord injury (SCI), motor commands from the brain are unable to reach peripheral nerves and muscles below the level of the lesion. Action observation (AO), in which a person observes someone else performing an action, has been used to augment traditional rehabilitation paradigms. Similarly, AO can be used to derive the relationship between brain activity and movement kinematics for a motor-based brain-computer interface (BCI) even when the user cannot generate overt movements. BCIs use brain signals to control external devices to replace functions that have been lost due to SCI or other motor impairment. Previous studies have reported congruent motor cortical activity during observed and overt movements using magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI). Recent single-unit studies using intracortical microelectrodes also demonstrated that a large number of motor cortical neurons had similar firing rate patterns between overt and observed movements. Given the increasing interest in electrocorticography (ECoG)-based BCIs, our goal was to identify whether action observation-related cortical activity could be recorded using ECoG during grasping tasks. Specifically, we aimed to identify congruent neural activity during observed and executed movements in both the sensorimotor rhythm (10–40 Hz) and the high-gamma band (65–115 Hz) which contains significant movement-related information. We observed significant motor-related high-gamma band activity during AO in both able-bodied individuals and one participant with a complete C4 SCI. Furthermore, in able-bodied participants, both the low and high frequency bands demonstrated congruent activity between action execution and observation. Our results suggest that AO could be an effective and critical procedure for deriving the mapping from ECoG signals to intended movement for an ECoG-based BCI system for individuals with paralysis. Frontiers Media S.A. 2014-02-19 /pmc/articles/PMC3928793/ /pubmed/24600359 http://dx.doi.org/10.3389/fnint.2014.00017 Text en Copyright © 2014 Collinger, Vinjamuri, Degenhart, Weber, Sudre, Boninger, Tyler-Kabara and Wang. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Collinger, Jennifer L.
Vinjamuri, Ramana
Degenhart, Alan D.
Weber, Douglas J.
Sudre, Gustavo P.
Boninger, Michael L.
Tyler-Kabara, Elizabeth C.
Wang, Wei
Motor-related brain activity during action observation: a neural substrate for electrocorticographic brain-computer interfaces after spinal cord injury
title Motor-related brain activity during action observation: a neural substrate for electrocorticographic brain-computer interfaces after spinal cord injury
title_full Motor-related brain activity during action observation: a neural substrate for electrocorticographic brain-computer interfaces after spinal cord injury
title_fullStr Motor-related brain activity during action observation: a neural substrate for electrocorticographic brain-computer interfaces after spinal cord injury
title_full_unstemmed Motor-related brain activity during action observation: a neural substrate for electrocorticographic brain-computer interfaces after spinal cord injury
title_short Motor-related brain activity during action observation: a neural substrate for electrocorticographic brain-computer interfaces after spinal cord injury
title_sort motor-related brain activity during action observation: a neural substrate for electrocorticographic brain-computer interfaces after spinal cord injury
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928793/
https://www.ncbi.nlm.nih.gov/pubmed/24600359
http://dx.doi.org/10.3389/fnint.2014.00017
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