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Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats

BACKGROUND: The public conviction that ‘herbal remedies are safe’ has led to an increased consumption of these products. This study was performed in view of the wide distribution of herbal remedies, the risks posed by self-treatment with these products, and the existing reports about the toxic effec...

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Autores principales: Movahedian, Ahmad, Asgary, Sedigheh, Mansoorkhani, Hossein Sadeghi, keshvari, Mahtab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928848/
https://www.ncbi.nlm.nih.gov/pubmed/24592365
http://dx.doi.org/10.4103/2277-9175.124641
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author Movahedian, Ahmad
Asgary, Sedigheh
Mansoorkhani, Hossein Sadeghi
keshvari, Mahtab
author_facet Movahedian, Ahmad
Asgary, Sedigheh
Mansoorkhani, Hossein Sadeghi
keshvari, Mahtab
author_sort Movahedian, Ahmad
collection PubMed
description BACKGROUND: The public conviction that ‘herbal remedies are safe’ has led to an increased consumption of these products. This study was performed in view of the wide distribution of herbal remedies, the risks posed by self-treatment with these products, and the existing reports about the toxic effects of some medicinal herbs. MATERIALS AND METHODS: In this study the effect of some of the most used herbal drops of A, B, C, and D on the liver function of rats was examined at different doses, namely minimum dose, maximum dose, and 2.5 times the maximum dose indicated in the brochures. The rats were administered the said doses via a feeding tube for 50 days. The liver function parameters including aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), total serum protein, albumin, and urea were measured using the spectrophotometric method. RESULTS: The animals’ liver tissues were examined pathologically. The A drop did not change the liver function parameters significantly. The B drop increased the LDH by 34% compared to the controls, at the maximum administered dose. The C and D drops increased the ALT, AST, and LDH significantly compared to the controls. The histological findings suggest the possible effect of C and D drops on the function of hepatocytes. CONCLUSIONS: We recommend that the herbal formulations available in pharmaceutical markets be more closely controlled in terms of quality, as well as toxicity, especially with regard to the possible effects on the hepatic function.
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spelling pubmed-39288482014-03-03 Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats Movahedian, Ahmad Asgary, Sedigheh Mansoorkhani, Hossein Sadeghi keshvari, Mahtab Adv Biomed Res Original Article BACKGROUND: The public conviction that ‘herbal remedies are safe’ has led to an increased consumption of these products. This study was performed in view of the wide distribution of herbal remedies, the risks posed by self-treatment with these products, and the existing reports about the toxic effects of some medicinal herbs. MATERIALS AND METHODS: In this study the effect of some of the most used herbal drops of A, B, C, and D on the liver function of rats was examined at different doses, namely minimum dose, maximum dose, and 2.5 times the maximum dose indicated in the brochures. The rats were administered the said doses via a feeding tube for 50 days. The liver function parameters including aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), total serum protein, albumin, and urea were measured using the spectrophotometric method. RESULTS: The animals’ liver tissues were examined pathologically. The A drop did not change the liver function parameters significantly. The B drop increased the LDH by 34% compared to the controls, at the maximum administered dose. The C and D drops increased the ALT, AST, and LDH significantly compared to the controls. The histological findings suggest the possible effect of C and D drops on the function of hepatocytes. CONCLUSIONS: We recommend that the herbal formulations available in pharmaceutical markets be more closely controlled in terms of quality, as well as toxicity, especially with regard to the possible effects on the hepatic function. Medknow Publications & Media Pvt Ltd 2014-01-09 /pmc/articles/PMC3928848/ /pubmed/24592365 http://dx.doi.org/10.4103/2277-9175.124641 Text en Copyright: © 2014 Movahedian. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Movahedian, Ahmad
Asgary, Sedigheh
Mansoorkhani, Hossein Sadeghi
keshvari, Mahtab
Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats
title Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats
title_full Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats
title_fullStr Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats
title_full_unstemmed Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats
title_short Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats
title_sort hepatotoxicity effect of some iranian medicinal herbal formulation on rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928848/
https://www.ncbi.nlm.nih.gov/pubmed/24592365
http://dx.doi.org/10.4103/2277-9175.124641
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