Cargando…
Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats
BACKGROUND: The public conviction that ‘herbal remedies are safe’ has led to an increased consumption of these products. This study was performed in view of the wide distribution of herbal remedies, the risks posed by self-treatment with these products, and the existing reports about the toxic effec...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928848/ https://www.ncbi.nlm.nih.gov/pubmed/24592365 http://dx.doi.org/10.4103/2277-9175.124641 |
_version_ | 1782304321728151552 |
---|---|
author | Movahedian, Ahmad Asgary, Sedigheh Mansoorkhani, Hossein Sadeghi keshvari, Mahtab |
author_facet | Movahedian, Ahmad Asgary, Sedigheh Mansoorkhani, Hossein Sadeghi keshvari, Mahtab |
author_sort | Movahedian, Ahmad |
collection | PubMed |
description | BACKGROUND: The public conviction that ‘herbal remedies are safe’ has led to an increased consumption of these products. This study was performed in view of the wide distribution of herbal remedies, the risks posed by self-treatment with these products, and the existing reports about the toxic effects of some medicinal herbs. MATERIALS AND METHODS: In this study the effect of some of the most used herbal drops of A, B, C, and D on the liver function of rats was examined at different doses, namely minimum dose, maximum dose, and 2.5 times the maximum dose indicated in the brochures. The rats were administered the said doses via a feeding tube for 50 days. The liver function parameters including aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), total serum protein, albumin, and urea were measured using the spectrophotometric method. RESULTS: The animals’ liver tissues were examined pathologically. The A drop did not change the liver function parameters significantly. The B drop increased the LDH by 34% compared to the controls, at the maximum administered dose. The C and D drops increased the ALT, AST, and LDH significantly compared to the controls. The histological findings suggest the possible effect of C and D drops on the function of hepatocytes. CONCLUSIONS: We recommend that the herbal formulations available in pharmaceutical markets be more closely controlled in terms of quality, as well as toxicity, especially with regard to the possible effects on the hepatic function. |
format | Online Article Text |
id | pubmed-3928848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39288482014-03-03 Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats Movahedian, Ahmad Asgary, Sedigheh Mansoorkhani, Hossein Sadeghi keshvari, Mahtab Adv Biomed Res Original Article BACKGROUND: The public conviction that ‘herbal remedies are safe’ has led to an increased consumption of these products. This study was performed in view of the wide distribution of herbal remedies, the risks posed by self-treatment with these products, and the existing reports about the toxic effects of some medicinal herbs. MATERIALS AND METHODS: In this study the effect of some of the most used herbal drops of A, B, C, and D on the liver function of rats was examined at different doses, namely minimum dose, maximum dose, and 2.5 times the maximum dose indicated in the brochures. The rats were administered the said doses via a feeding tube for 50 days. The liver function parameters including aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), total serum protein, albumin, and urea were measured using the spectrophotometric method. RESULTS: The animals’ liver tissues were examined pathologically. The A drop did not change the liver function parameters significantly. The B drop increased the LDH by 34% compared to the controls, at the maximum administered dose. The C and D drops increased the ALT, AST, and LDH significantly compared to the controls. The histological findings suggest the possible effect of C and D drops on the function of hepatocytes. CONCLUSIONS: We recommend that the herbal formulations available in pharmaceutical markets be more closely controlled in terms of quality, as well as toxicity, especially with regard to the possible effects on the hepatic function. Medknow Publications & Media Pvt Ltd 2014-01-09 /pmc/articles/PMC3928848/ /pubmed/24592365 http://dx.doi.org/10.4103/2277-9175.124641 Text en Copyright: © 2014 Movahedian. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Movahedian, Ahmad Asgary, Sedigheh Mansoorkhani, Hossein Sadeghi keshvari, Mahtab Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats |
title | Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats |
title_full | Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats |
title_fullStr | Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats |
title_full_unstemmed | Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats |
title_short | Hepatotoxicity effect of some Iranian medicinal herbal formulation on rats |
title_sort | hepatotoxicity effect of some iranian medicinal herbal formulation on rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928848/ https://www.ncbi.nlm.nih.gov/pubmed/24592365 http://dx.doi.org/10.4103/2277-9175.124641 |
work_keys_str_mv | AT movahedianahmad hepatotoxicityeffectofsomeiranianmedicinalherbalformulationonrats AT asgarysedigheh hepatotoxicityeffectofsomeiranianmedicinalherbalformulationonrats AT mansoorkhanihosseinsadeghi hepatotoxicityeffectofsomeiranianmedicinalherbalformulationonrats AT keshvarimahtab hepatotoxicityeffectofsomeiranianmedicinalherbalformulationonrats |