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The effect of conjugated linoleic acids and omega-3 fatty acids supplementation on lipid profile in atherosclerosis

BACKGROUND: Cardiovascular diseases (CVD) are the most serious cause of mortality in developed and developing countries. Epidemiological studies indicated that dyslipidemia is the major risk factor of CVD. Dyslipidemia can be modified either by proper lifestyle or medical intervention or by the comb...

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Autores principales: Eftekhari, Mohammad Hassan, Aliasghari, Fereshte, Beigi, Mohammad Ali Babaei, Hasanzadeh, Jafar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929013/
https://www.ncbi.nlm.nih.gov/pubmed/24600599
http://dx.doi.org/10.4103/2277-9175.124644
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author Eftekhari, Mohammad Hassan
Aliasghari, Fereshte
Beigi, Mohammad Ali Babaei
Hasanzadeh, Jafar
author_facet Eftekhari, Mohammad Hassan
Aliasghari, Fereshte
Beigi, Mohammad Ali Babaei
Hasanzadeh, Jafar
author_sort Eftekhari, Mohammad Hassan
collection PubMed
description BACKGROUND: Cardiovascular diseases (CVD) are the most serious cause of mortality in developed and developing countries. Epidemiological studies indicated that dyslipidemia is the major risk factor of CVD. Dyslipidemia can be modified either by proper lifestyle or medical intervention or by the combination of both. Conjugated linoleic acids (CLA) and ω3 fatty acids have beneficial effects on plasma lipids and lipoproteins. The aim of this study was to evaluate the effect of CLA and omega-3 fatty acids (ω-3 fatty acids) supplementation on lipid profile in atherosclerosis patient. MATERIALS AND METHODS: This study was a 2-month clinical randomized trial. Ninety atherosclerotic patients with angiographically diagnosed coronary atherosclerosis who were referred to Emam Reza Heart Clinic of Shiraz University of Medical Sciences from February to march 2011 were selected if they fulfilled the inclusion criteria. The participants were randomly classified into 3 groups receiving 3 g/d CLA or 1 920 mg/d ω3 or placebo for 2 months. High-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides (TG), and total cholesterol were measured before and after the intervention. This study was a two-month clinical randomized trial. RESULTS: Data were analyzed using SPSS software (SPSS Inc, Chicago, version19). Although CLA did not appear to have a significant effect on TG, ω3 supplementation significantly reduced TG level. Consumption of CLA and ω3 supplementation did not significantly affect HDL cholesterol, LDL cholesterol, and total cholesterol. CONCLUSIONS: ω3 supplementation significantly reduced TG level but CLA and ω3 did not show significant changes in other indices of lipid profile in atherosclerotic patients.
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spelling pubmed-39290132014-03-05 The effect of conjugated linoleic acids and omega-3 fatty acids supplementation on lipid profile in atherosclerosis Eftekhari, Mohammad Hassan Aliasghari, Fereshte Beigi, Mohammad Ali Babaei Hasanzadeh, Jafar Adv Biomed Res Original Article BACKGROUND: Cardiovascular diseases (CVD) are the most serious cause of mortality in developed and developing countries. Epidemiological studies indicated that dyslipidemia is the major risk factor of CVD. Dyslipidemia can be modified either by proper lifestyle or medical intervention or by the combination of both. Conjugated linoleic acids (CLA) and ω3 fatty acids have beneficial effects on plasma lipids and lipoproteins. The aim of this study was to evaluate the effect of CLA and omega-3 fatty acids (ω-3 fatty acids) supplementation on lipid profile in atherosclerosis patient. MATERIALS AND METHODS: This study was a 2-month clinical randomized trial. Ninety atherosclerotic patients with angiographically diagnosed coronary atherosclerosis who were referred to Emam Reza Heart Clinic of Shiraz University of Medical Sciences from February to march 2011 were selected if they fulfilled the inclusion criteria. The participants were randomly classified into 3 groups receiving 3 g/d CLA or 1 920 mg/d ω3 or placebo for 2 months. High-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides (TG), and total cholesterol were measured before and after the intervention. This study was a two-month clinical randomized trial. RESULTS: Data were analyzed using SPSS software (SPSS Inc, Chicago, version19). Although CLA did not appear to have a significant effect on TG, ω3 supplementation significantly reduced TG level. Consumption of CLA and ω3 supplementation did not significantly affect HDL cholesterol, LDL cholesterol, and total cholesterol. CONCLUSIONS: ω3 supplementation significantly reduced TG level but CLA and ω3 did not show significant changes in other indices of lipid profile in atherosclerotic patients. Medknow Publications & Media Pvt Ltd 2014-01-09 /pmc/articles/PMC3929013/ /pubmed/24600599 http://dx.doi.org/10.4103/2277-9175.124644 Text en Copyright: © 2014 Eftekhari. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Eftekhari, Mohammad Hassan
Aliasghari, Fereshte
Beigi, Mohammad Ali Babaei
Hasanzadeh, Jafar
The effect of conjugated linoleic acids and omega-3 fatty acids supplementation on lipid profile in atherosclerosis
title The effect of conjugated linoleic acids and omega-3 fatty acids supplementation on lipid profile in atherosclerosis
title_full The effect of conjugated linoleic acids and omega-3 fatty acids supplementation on lipid profile in atherosclerosis
title_fullStr The effect of conjugated linoleic acids and omega-3 fatty acids supplementation on lipid profile in atherosclerosis
title_full_unstemmed The effect of conjugated linoleic acids and omega-3 fatty acids supplementation on lipid profile in atherosclerosis
title_short The effect of conjugated linoleic acids and omega-3 fatty acids supplementation on lipid profile in atherosclerosis
title_sort effect of conjugated linoleic acids and omega-3 fatty acids supplementation on lipid profile in atherosclerosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929013/
https://www.ncbi.nlm.nih.gov/pubmed/24600599
http://dx.doi.org/10.4103/2277-9175.124644
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