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Primary frozen shoulder: brief review of pathology and imaging abnormalities
BACKGROUND: Primary frozen shoulder (FS) is a painful contracture of the glenohumeral joint that arises spontaneously without an obvious preceding event. Investigation of the intra-articular and periarticular pathology would contribute to the treatment of primary FS. REVIEW OF LITERATURE: Many studi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929028/ https://www.ncbi.nlm.nih.gov/pubmed/24306579 http://dx.doi.org/10.1007/s00776-013-0495-x |
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author | Tamai, Kazuya Akutsu, Miwa Yano, Yuichiro |
author_facet | Tamai, Kazuya Akutsu, Miwa Yano, Yuichiro |
author_sort | Tamai, Kazuya |
collection | PubMed |
description | BACKGROUND: Primary frozen shoulder (FS) is a painful contracture of the glenohumeral joint that arises spontaneously without an obvious preceding event. Investigation of the intra-articular and periarticular pathology would contribute to the treatment of primary FS. REVIEW OF LITERATURE: Many studies indicate that the main pathology is an inflammatory contracture of the shoulder joint capsule. This is associated with an increased amount of collagen, fibrotic growth factors such as transforming growth factor-beta, and inflammatory cytokines such as tumor necrosis factor-alpha and interleukins. Immune system cells such as B-lymphocytes, T-lymphocytes and macrophages are also noted. Active fibroblastic proliferation similar to that of Dupuytren’s contracture is documented. Presence of inflammation in the FS synovium is supported by the synovial enhancement with dynamic magnetic resonance study in the clinical setting. CONCLUSION: Primary FS shows fibrosis of the joint capsule, associated with preceding synovitis. The initiator of synovitis, however, still remains unclear. Future studies should be directed to give light to the pathogenesis of inflammation to better treat or prevent primary FS. |
format | Online Article Text |
id | pubmed-3929028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-39290282014-02-25 Primary frozen shoulder: brief review of pathology and imaging abnormalities Tamai, Kazuya Akutsu, Miwa Yano, Yuichiro J Orthop Sci Review Article BACKGROUND: Primary frozen shoulder (FS) is a painful contracture of the glenohumeral joint that arises spontaneously without an obvious preceding event. Investigation of the intra-articular and periarticular pathology would contribute to the treatment of primary FS. REVIEW OF LITERATURE: Many studies indicate that the main pathology is an inflammatory contracture of the shoulder joint capsule. This is associated with an increased amount of collagen, fibrotic growth factors such as transforming growth factor-beta, and inflammatory cytokines such as tumor necrosis factor-alpha and interleukins. Immune system cells such as B-lymphocytes, T-lymphocytes and macrophages are also noted. Active fibroblastic proliferation similar to that of Dupuytren’s contracture is documented. Presence of inflammation in the FS synovium is supported by the synovial enhancement with dynamic magnetic resonance study in the clinical setting. CONCLUSION: Primary FS shows fibrosis of the joint capsule, associated with preceding synovitis. The initiator of synovitis, however, still remains unclear. Future studies should be directed to give light to the pathogenesis of inflammation to better treat or prevent primary FS. Springer Japan 2013-12-04 2014 /pmc/articles/PMC3929028/ /pubmed/24306579 http://dx.doi.org/10.1007/s00776-013-0495-x Text en © The Japanese Orthopaedic Association 2013 |
spellingShingle | Review Article Tamai, Kazuya Akutsu, Miwa Yano, Yuichiro Primary frozen shoulder: brief review of pathology and imaging abnormalities |
title | Primary frozen shoulder: brief review of pathology and imaging abnormalities |
title_full | Primary frozen shoulder: brief review of pathology and imaging abnormalities |
title_fullStr | Primary frozen shoulder: brief review of pathology and imaging abnormalities |
title_full_unstemmed | Primary frozen shoulder: brief review of pathology and imaging abnormalities |
title_short | Primary frozen shoulder: brief review of pathology and imaging abnormalities |
title_sort | primary frozen shoulder: brief review of pathology and imaging abnormalities |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929028/ https://www.ncbi.nlm.nih.gov/pubmed/24306579 http://dx.doi.org/10.1007/s00776-013-0495-x |
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