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Primary frozen shoulder: brief review of pathology and imaging abnormalities

BACKGROUND: Primary frozen shoulder (FS) is a painful contracture of the glenohumeral joint that arises spontaneously without an obvious preceding event. Investigation of the intra-articular and periarticular pathology would contribute to the treatment of primary FS. REVIEW OF LITERATURE: Many studi...

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Detalles Bibliográficos
Autores principales: Tamai, Kazuya, Akutsu, Miwa, Yano, Yuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929028/
https://www.ncbi.nlm.nih.gov/pubmed/24306579
http://dx.doi.org/10.1007/s00776-013-0495-x
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author Tamai, Kazuya
Akutsu, Miwa
Yano, Yuichiro
author_facet Tamai, Kazuya
Akutsu, Miwa
Yano, Yuichiro
author_sort Tamai, Kazuya
collection PubMed
description BACKGROUND: Primary frozen shoulder (FS) is a painful contracture of the glenohumeral joint that arises spontaneously without an obvious preceding event. Investigation of the intra-articular and periarticular pathology would contribute to the treatment of primary FS. REVIEW OF LITERATURE: Many studies indicate that the main pathology is an inflammatory contracture of the shoulder joint capsule. This is associated with an increased amount of collagen, fibrotic growth factors such as transforming growth factor-beta, and inflammatory cytokines such as tumor necrosis factor-alpha and interleukins. Immune system cells such as B-lymphocytes, T-lymphocytes and macrophages are also noted. Active fibroblastic proliferation similar to that of Dupuytren’s contracture is documented. Presence of inflammation in the FS synovium is supported by the synovial enhancement with dynamic magnetic resonance study in the clinical setting. CONCLUSION: Primary FS shows fibrosis of the joint capsule, associated with preceding synovitis. The initiator of synovitis, however, still remains unclear. Future studies should be directed to give light to the pathogenesis of inflammation to better treat or prevent primary FS.
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spelling pubmed-39290282014-02-25 Primary frozen shoulder: brief review of pathology and imaging abnormalities Tamai, Kazuya Akutsu, Miwa Yano, Yuichiro J Orthop Sci Review Article BACKGROUND: Primary frozen shoulder (FS) is a painful contracture of the glenohumeral joint that arises spontaneously without an obvious preceding event. Investigation of the intra-articular and periarticular pathology would contribute to the treatment of primary FS. REVIEW OF LITERATURE: Many studies indicate that the main pathology is an inflammatory contracture of the shoulder joint capsule. This is associated with an increased amount of collagen, fibrotic growth factors such as transforming growth factor-beta, and inflammatory cytokines such as tumor necrosis factor-alpha and interleukins. Immune system cells such as B-lymphocytes, T-lymphocytes and macrophages are also noted. Active fibroblastic proliferation similar to that of Dupuytren’s contracture is documented. Presence of inflammation in the FS synovium is supported by the synovial enhancement with dynamic magnetic resonance study in the clinical setting. CONCLUSION: Primary FS shows fibrosis of the joint capsule, associated with preceding synovitis. The initiator of synovitis, however, still remains unclear. Future studies should be directed to give light to the pathogenesis of inflammation to better treat or prevent primary FS. Springer Japan 2013-12-04 2014 /pmc/articles/PMC3929028/ /pubmed/24306579 http://dx.doi.org/10.1007/s00776-013-0495-x Text en © The Japanese Orthopaedic Association 2013
spellingShingle Review Article
Tamai, Kazuya
Akutsu, Miwa
Yano, Yuichiro
Primary frozen shoulder: brief review of pathology and imaging abnormalities
title Primary frozen shoulder: brief review of pathology and imaging abnormalities
title_full Primary frozen shoulder: brief review of pathology and imaging abnormalities
title_fullStr Primary frozen shoulder: brief review of pathology and imaging abnormalities
title_full_unstemmed Primary frozen shoulder: brief review of pathology and imaging abnormalities
title_short Primary frozen shoulder: brief review of pathology and imaging abnormalities
title_sort primary frozen shoulder: brief review of pathology and imaging abnormalities
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929028/
https://www.ncbi.nlm.nih.gov/pubmed/24306579
http://dx.doi.org/10.1007/s00776-013-0495-x
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