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LncRNAs: New Players in Apoptosis Control
The discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community. Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators invol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929073/ https://www.ncbi.nlm.nih.gov/pubmed/24627686 http://dx.doi.org/10.1155/2014/473857 |
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author | Rossi, Marianna Nicoletta Antonangeli, Fabrizio |
author_facet | Rossi, Marianna Nicoletta Antonangeli, Fabrizio |
author_sort | Rossi, Marianna Nicoletta |
collection | PubMed |
description | The discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community. Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators involved not only in physiological processes, such as imprinting and differentiation, but also in cancer progression and neurodegeneration. Apoptosis is a well regulated type of programmed cell death necessary for correct organ development and tissue homeostasis. Indeed, cancer cells often show an inhibition of the apoptotic pathways and it is now emerging that overexpression or downregulation of different lncRNAs in specific types of tumors sensitize cancer cells to apoptotic stimuli. In this review we summarize the latest studies on lncRNAs and apoptosis with major attention to those performed in cancer cells and in healthy cells upon differentiation. We discuss the new perspectives of using lncRNAs as targets of anticancer drugs. Finally, considering that lncRNA levels have been reported to have a correlation with specific cancer types, we argue the possibility of using lncRNAs as tumor biomarkers. |
format | Online Article Text |
id | pubmed-3929073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39290732014-03-13 LncRNAs: New Players in Apoptosis Control Rossi, Marianna Nicoletta Antonangeli, Fabrizio Int J Cell Biol Review Article The discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community. Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators involved not only in physiological processes, such as imprinting and differentiation, but also in cancer progression and neurodegeneration. Apoptosis is a well regulated type of programmed cell death necessary for correct organ development and tissue homeostasis. Indeed, cancer cells often show an inhibition of the apoptotic pathways and it is now emerging that overexpression or downregulation of different lncRNAs in specific types of tumors sensitize cancer cells to apoptotic stimuli. In this review we summarize the latest studies on lncRNAs and apoptosis with major attention to those performed in cancer cells and in healthy cells upon differentiation. We discuss the new perspectives of using lncRNAs as targets of anticancer drugs. Finally, considering that lncRNA levels have been reported to have a correlation with specific cancer types, we argue the possibility of using lncRNAs as tumor biomarkers. Hindawi Publishing Corporation 2014 2014-01-30 /pmc/articles/PMC3929073/ /pubmed/24627686 http://dx.doi.org/10.1155/2014/473857 Text en Copyright © 2014 M. N. Rossi and F. Antonangeli. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rossi, Marianna Nicoletta Antonangeli, Fabrizio LncRNAs: New Players in Apoptosis Control |
title | LncRNAs: New Players in Apoptosis Control |
title_full | LncRNAs: New Players in Apoptosis Control |
title_fullStr | LncRNAs: New Players in Apoptosis Control |
title_full_unstemmed | LncRNAs: New Players in Apoptosis Control |
title_short | LncRNAs: New Players in Apoptosis Control |
title_sort | lncrnas: new players in apoptosis control |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929073/ https://www.ncbi.nlm.nih.gov/pubmed/24627686 http://dx.doi.org/10.1155/2014/473857 |
work_keys_str_mv | AT rossimariannanicoletta lncrnasnewplayersinapoptosiscontrol AT antonangelifabrizio lncrnasnewplayersinapoptosiscontrol |