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LncRNAs: New Players in Apoptosis Control

The discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community. Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators invol...

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Detalles Bibliográficos
Autores principales: Rossi, Marianna Nicoletta, Antonangeli, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929073/
https://www.ncbi.nlm.nih.gov/pubmed/24627686
http://dx.doi.org/10.1155/2014/473857
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author Rossi, Marianna Nicoletta
Antonangeli, Fabrizio
author_facet Rossi, Marianna Nicoletta
Antonangeli, Fabrizio
author_sort Rossi, Marianna Nicoletta
collection PubMed
description The discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community. Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators involved not only in physiological processes, such as imprinting and differentiation, but also in cancer progression and neurodegeneration. Apoptosis is a well regulated type of programmed cell death necessary for correct organ development and tissue homeostasis. Indeed, cancer cells often show an inhibition of the apoptotic pathways and it is now emerging that overexpression or downregulation of different lncRNAs in specific types of tumors sensitize cancer cells to apoptotic stimuli. In this review we summarize the latest studies on lncRNAs and apoptosis with major attention to those performed in cancer cells and in healthy cells upon differentiation. We discuss the new perspectives of using lncRNAs as targets of anticancer drugs. Finally, considering that lncRNA levels have been reported to have a correlation with specific cancer types, we argue the possibility of using lncRNAs as tumor biomarkers.
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spelling pubmed-39290732014-03-13 LncRNAs: New Players in Apoptosis Control Rossi, Marianna Nicoletta Antonangeli, Fabrizio Int J Cell Biol Review Article The discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community. Growing amount of data suggests that long noncoding RNAs (lncRNAs) are a new class of regulators involved not only in physiological processes, such as imprinting and differentiation, but also in cancer progression and neurodegeneration. Apoptosis is a well regulated type of programmed cell death necessary for correct organ development and tissue homeostasis. Indeed, cancer cells often show an inhibition of the apoptotic pathways and it is now emerging that overexpression or downregulation of different lncRNAs in specific types of tumors sensitize cancer cells to apoptotic stimuli. In this review we summarize the latest studies on lncRNAs and apoptosis with major attention to those performed in cancer cells and in healthy cells upon differentiation. We discuss the new perspectives of using lncRNAs as targets of anticancer drugs. Finally, considering that lncRNA levels have been reported to have a correlation with specific cancer types, we argue the possibility of using lncRNAs as tumor biomarkers. Hindawi Publishing Corporation 2014 2014-01-30 /pmc/articles/PMC3929073/ /pubmed/24627686 http://dx.doi.org/10.1155/2014/473857 Text en Copyright © 2014 M. N. Rossi and F. Antonangeli. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rossi, Marianna Nicoletta
Antonangeli, Fabrizio
LncRNAs: New Players in Apoptosis Control
title LncRNAs: New Players in Apoptosis Control
title_full LncRNAs: New Players in Apoptosis Control
title_fullStr LncRNAs: New Players in Apoptosis Control
title_full_unstemmed LncRNAs: New Players in Apoptosis Control
title_short LncRNAs: New Players in Apoptosis Control
title_sort lncrnas: new players in apoptosis control
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929073/
https://www.ncbi.nlm.nih.gov/pubmed/24627686
http://dx.doi.org/10.1155/2014/473857
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