Gasotransmitter Regulation of Ion Channels: A Key Step in O(2) Sensing By the Carotid Body

Carotid bodies detect hypoxia in arterial blood, translating this stimulus into physiological responses via the CNS. It is long established that ion channels are critical to this process. More recent evidence indicates that gasotransmitters exert powerful influences on O(2) sensing by the carotid bo...

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Detalles Bibliográficos
Autores principales: Prabhakar, Nanduri R., Peers, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929115/
https://www.ncbi.nlm.nih.gov/pubmed/24382871
http://dx.doi.org/10.1152/physiol.00034.2013
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author Prabhakar, Nanduri R.
Peers, Chris
author_facet Prabhakar, Nanduri R.
Peers, Chris
author_sort Prabhakar, Nanduri R.
collection PubMed
description Carotid bodies detect hypoxia in arterial blood, translating this stimulus into physiological responses via the CNS. It is long established that ion channels are critical to this process. More recent evidence indicates that gasotransmitters exert powerful influences on O(2) sensing by the carotid body. Here, we review current understanding of hypoxia-dependent production of gasotransmitters, how they regulate ion channels in the carotid body, and how this impacts carotid body function.
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spelling pubmed-39291152014-08-06 Gasotransmitter Regulation of Ion Channels: A Key Step in O(2) Sensing By the Carotid Body Prabhakar, Nanduri R. Peers, Chris Physiology (Bethesda) Reviews Carotid bodies detect hypoxia in arterial blood, translating this stimulus into physiological responses via the CNS. It is long established that ion channels are critical to this process. More recent evidence indicates that gasotransmitters exert powerful influences on O(2) sensing by the carotid body. Here, we review current understanding of hypoxia-dependent production of gasotransmitters, how they regulate ion channels in the carotid body, and how this impacts carotid body function. American Physiological Society 2014-01 /pmc/articles/PMC3929115/ /pubmed/24382871 http://dx.doi.org/10.1152/physiol.00034.2013 Text en ©2014 Int. Union Physiol. Sci./Am. Physiol. Soc. Licensed under Creative Commons Attribution CC-BY 3.0 (http://creativecommons.org/licenses/by/3.0/deed.en_US) : the American Physiological Society.
spellingShingle Reviews
Prabhakar, Nanduri R.
Peers, Chris
Gasotransmitter Regulation of Ion Channels: A Key Step in O(2) Sensing By the Carotid Body
title Gasotransmitter Regulation of Ion Channels: A Key Step in O(2) Sensing By the Carotid Body
title_full Gasotransmitter Regulation of Ion Channels: A Key Step in O(2) Sensing By the Carotid Body
title_fullStr Gasotransmitter Regulation of Ion Channels: A Key Step in O(2) Sensing By the Carotid Body
title_full_unstemmed Gasotransmitter Regulation of Ion Channels: A Key Step in O(2) Sensing By the Carotid Body
title_short Gasotransmitter Regulation of Ion Channels: A Key Step in O(2) Sensing By the Carotid Body
title_sort gasotransmitter regulation of ion channels: a key step in o(2) sensing by the carotid body
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929115/
https://www.ncbi.nlm.nih.gov/pubmed/24382871
http://dx.doi.org/10.1152/physiol.00034.2013
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