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Waist circumference and insulin resistance in elderly men: an analysis of Kahrizak elderly study

BACKGROUND: Diagnosis of the metabolic syndrome (MS) is crucial for health care practitioners to identify at risk people for early treatment. Visceral obesity may make unnecessary other laborious measures of insulin resistance. The aim of this study was to see whether waist circumference (WC) can pr...

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Autores principales: Mirarefin, Mojdeh, Sharifi, Farshad, Fakhrzadeh, Hossein, Amini, Mohammad Reza, Ghaderpanahi, Maryam, Shoa, Nahid Zerafati, Badamchizadeh, Zohreh, TajalizadeKhoob, Yaser, Nazari, Neda, Larijani, Bagher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929157/
https://www.ncbi.nlm.nih.gov/pubmed/24495315
http://dx.doi.org/10.1186/2251-6581-13-28
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author Mirarefin, Mojdeh
Sharifi, Farshad
Fakhrzadeh, Hossein
Amini, Mohammad Reza
Ghaderpanahi, Maryam
Shoa, Nahid Zerafati
Badamchizadeh, Zohreh
TajalizadeKhoob, Yaser
Nazari, Neda
Larijani, Bagher
author_facet Mirarefin, Mojdeh
Sharifi, Farshad
Fakhrzadeh, Hossein
Amini, Mohammad Reza
Ghaderpanahi, Maryam
Shoa, Nahid Zerafati
Badamchizadeh, Zohreh
TajalizadeKhoob, Yaser
Nazari, Neda
Larijani, Bagher
author_sort Mirarefin, Mojdeh
collection PubMed
description BACKGROUND: Diagnosis of the metabolic syndrome (MS) is crucial for health care practitioners to identify at risk people for early treatment. Visceral obesity may make unnecessary other laborious measures of insulin resistance. The aim of this study was to see whether waist circumference (WC) can predict insulin resistance as well as MS in a group of Iranian elderly. METHODS: Out of 94 nondiabetic elderly, thirty three subjects were recognized with MS. MS diagnosis was based on NCEP ATP III (National Cholesterol Education Program Adult Treatment Panel III) and IDF (International Diabetes Federation) definitions. HOMA (Homeostasis Model Assessment) index was used to measure insulin sensitivity. Insulin resistance (IR) was defined as top quartile of HOMA. RESULTS: In both sexes, WC and HOMA index were significantly positively correlated. The optimal waist circumference (OWC) cutoff point was 94.5 cm for men and 90.5 cm for women. The high sensitivity (0.80) and specificity (0.84) of WC in males indicates the proportion of IR which is correctly identified and recognizes all non-IR males as such. In regression model only the TG level was associated with WC. But the WC is strongly associated with HOMA-IR. CONCLUSIONS: While OWC is very likely a good measure to exclude non-IR subjects in our study, determination of optimal WC to identify elderly IR subjects warrants further study in a larger sample of the general population.
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spelling pubmed-39291572014-02-20 Waist circumference and insulin resistance in elderly men: an analysis of Kahrizak elderly study Mirarefin, Mojdeh Sharifi, Farshad Fakhrzadeh, Hossein Amini, Mohammad Reza Ghaderpanahi, Maryam Shoa, Nahid Zerafati Badamchizadeh, Zohreh TajalizadeKhoob, Yaser Nazari, Neda Larijani, Bagher J Diabetes Metab Disord Research Article BACKGROUND: Diagnosis of the metabolic syndrome (MS) is crucial for health care practitioners to identify at risk people for early treatment. Visceral obesity may make unnecessary other laborious measures of insulin resistance. The aim of this study was to see whether waist circumference (WC) can predict insulin resistance as well as MS in a group of Iranian elderly. METHODS: Out of 94 nondiabetic elderly, thirty three subjects were recognized with MS. MS diagnosis was based on NCEP ATP III (National Cholesterol Education Program Adult Treatment Panel III) and IDF (International Diabetes Federation) definitions. HOMA (Homeostasis Model Assessment) index was used to measure insulin sensitivity. Insulin resistance (IR) was defined as top quartile of HOMA. RESULTS: In both sexes, WC and HOMA index were significantly positively correlated. The optimal waist circumference (OWC) cutoff point was 94.5 cm for men and 90.5 cm for women. The high sensitivity (0.80) and specificity (0.84) of WC in males indicates the proportion of IR which is correctly identified and recognizes all non-IR males as such. In regression model only the TG level was associated with WC. But the WC is strongly associated with HOMA-IR. CONCLUSIONS: While OWC is very likely a good measure to exclude non-IR subjects in our study, determination of optimal WC to identify elderly IR subjects warrants further study in a larger sample of the general population. BioMed Central 2014-02-04 /pmc/articles/PMC3929157/ /pubmed/24495315 http://dx.doi.org/10.1186/2251-6581-13-28 Text en Copyright © 2014 Mirarefin et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mirarefin, Mojdeh
Sharifi, Farshad
Fakhrzadeh, Hossein
Amini, Mohammad Reza
Ghaderpanahi, Maryam
Shoa, Nahid Zerafati
Badamchizadeh, Zohreh
TajalizadeKhoob, Yaser
Nazari, Neda
Larijani, Bagher
Waist circumference and insulin resistance in elderly men: an analysis of Kahrizak elderly study
title Waist circumference and insulin resistance in elderly men: an analysis of Kahrizak elderly study
title_full Waist circumference and insulin resistance in elderly men: an analysis of Kahrizak elderly study
title_fullStr Waist circumference and insulin resistance in elderly men: an analysis of Kahrizak elderly study
title_full_unstemmed Waist circumference and insulin resistance in elderly men: an analysis of Kahrizak elderly study
title_short Waist circumference and insulin resistance in elderly men: an analysis of Kahrizak elderly study
title_sort waist circumference and insulin resistance in elderly men: an analysis of kahrizak elderly study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929157/
https://www.ncbi.nlm.nih.gov/pubmed/24495315
http://dx.doi.org/10.1186/2251-6581-13-28
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