Cargando…

Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Attention/Deficit Hyperactivity Disorder, Learning Disability, and Special Education in U.S. Children Aged 6 to 15

Exposure to polycyclic aromatic hydrocarbons (PAHs) adversely affects child neurodevelopment, but little is known about the relationship between PAHs and clinically significant developmental disorders. We examined the relationship between childhood measures of PAH exposure and prevalence of attentio...

Descripción completa

Detalles Bibliográficos
Autores principales: Abid, Zaynah, Roy, Ananya, Herbstman, Julie B., Ettinger, Adrienne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929190/
https://www.ncbi.nlm.nih.gov/pubmed/24624143
http://dx.doi.org/10.1155/2014/628508
_version_ 1782304367624323072
author Abid, Zaynah
Roy, Ananya
Herbstman, Julie B.
Ettinger, Adrienne S.
author_facet Abid, Zaynah
Roy, Ananya
Herbstman, Julie B.
Ettinger, Adrienne S.
author_sort Abid, Zaynah
collection PubMed
description Exposure to polycyclic aromatic hydrocarbons (PAHs) adversely affects child neurodevelopment, but little is known about the relationship between PAHs and clinically significant developmental disorders. We examined the relationship between childhood measures of PAH exposure and prevalence of attention deficit/hyperactivity disorder (ADHD), learning disability (LD), and special education (SE) in a nationally representative sample of 1,257 U.S. children 6–15 years of age. Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001–2004. PAH exposure was measured by urinary metabolite concentrations. Outcomes were defined by parental report of (1) ever doctor-diagnosed ADHD, (2) ever doctor- or school representative-identified LD, and (3) receipt of SE or early intervention services. Multivariate logistic regression accounting for survey sampling was used to determine the associations between PAH metabolites and ADHD, LD, and SE. Children exposed to higher levels of fluorine metabolites had a 2-fold increased odds (95% C.I. 1.1, 3.8) of SE, and this association was more apparent in males (OR 2.3; 95% C.I. 1.2, 4.1) than in females (OR 1.8; 95% C.I. 0.6, 5.4). No other consistent pattern of developmental disorders was associated with urinary PAH metabolites. However, concurrent exposure to PAH fluorine metabolites may increase use of special education services among U.S. children.
format Online
Article
Text
id pubmed-3929190
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-39291902014-03-12 Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Attention/Deficit Hyperactivity Disorder, Learning Disability, and Special Education in U.S. Children Aged 6 to 15 Abid, Zaynah Roy, Ananya Herbstman, Julie B. Ettinger, Adrienne S. J Environ Public Health Research Article Exposure to polycyclic aromatic hydrocarbons (PAHs) adversely affects child neurodevelopment, but little is known about the relationship between PAHs and clinically significant developmental disorders. We examined the relationship between childhood measures of PAH exposure and prevalence of attention deficit/hyperactivity disorder (ADHD), learning disability (LD), and special education (SE) in a nationally representative sample of 1,257 U.S. children 6–15 years of age. Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001–2004. PAH exposure was measured by urinary metabolite concentrations. Outcomes were defined by parental report of (1) ever doctor-diagnosed ADHD, (2) ever doctor- or school representative-identified LD, and (3) receipt of SE or early intervention services. Multivariate logistic regression accounting for survey sampling was used to determine the associations between PAH metabolites and ADHD, LD, and SE. Children exposed to higher levels of fluorine metabolites had a 2-fold increased odds (95% C.I. 1.1, 3.8) of SE, and this association was more apparent in males (OR 2.3; 95% C.I. 1.2, 4.1) than in females (OR 1.8; 95% C.I. 0.6, 5.4). No other consistent pattern of developmental disorders was associated with urinary PAH metabolites. However, concurrent exposure to PAH fluorine metabolites may increase use of special education services among U.S. children. Hindawi Publishing Corporation 2014 2014-01-30 /pmc/articles/PMC3929190/ /pubmed/24624143 http://dx.doi.org/10.1155/2014/628508 Text en Copyright © 2014 Zaynah Abid et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Abid, Zaynah
Roy, Ananya
Herbstman, Julie B.
Ettinger, Adrienne S.
Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Attention/Deficit Hyperactivity Disorder, Learning Disability, and Special Education in U.S. Children Aged 6 to 15
title Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Attention/Deficit Hyperactivity Disorder, Learning Disability, and Special Education in U.S. Children Aged 6 to 15
title_full Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Attention/Deficit Hyperactivity Disorder, Learning Disability, and Special Education in U.S. Children Aged 6 to 15
title_fullStr Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Attention/Deficit Hyperactivity Disorder, Learning Disability, and Special Education in U.S. Children Aged 6 to 15
title_full_unstemmed Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Attention/Deficit Hyperactivity Disorder, Learning Disability, and Special Education in U.S. Children Aged 6 to 15
title_short Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Attention/Deficit Hyperactivity Disorder, Learning Disability, and Special Education in U.S. Children Aged 6 to 15
title_sort urinary polycyclic aromatic hydrocarbon metabolites and attention/deficit hyperactivity disorder, learning disability, and special education in u.s. children aged 6 to 15
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929190/
https://www.ncbi.nlm.nih.gov/pubmed/24624143
http://dx.doi.org/10.1155/2014/628508
work_keys_str_mv AT abidzaynah urinarypolycyclicaromatichydrocarbonmetabolitesandattentiondeficithyperactivitydisorderlearningdisabilityandspecialeducationinuschildrenaged6to15
AT royananya urinarypolycyclicaromatichydrocarbonmetabolitesandattentiondeficithyperactivitydisorderlearningdisabilityandspecialeducationinuschildrenaged6to15
AT herbstmanjulieb urinarypolycyclicaromatichydrocarbonmetabolitesandattentiondeficithyperactivitydisorderlearningdisabilityandspecialeducationinuschildrenaged6to15
AT ettingeradriennes urinarypolycyclicaromatichydrocarbonmetabolitesandattentiondeficithyperactivitydisorderlearningdisabilityandspecialeducationinuschildrenaged6to15