Cargando…
Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis
Background. We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1β levels in early rheumatoid arthritis (RA). These observations raised the hypothesis that drugs targeting the IL-1β pathway, in addition to tumour necrosis factor (TNF), may be particularly...
Autores principales: | Cascão, Rita, Vidal, Bruno, Raquel, Helena, Neves-Costa, Ana, Figueiredo, Nuno, Gupta, Vineet, Fonseca, João Eurico, Ferreira Moita, Luis |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929289/ https://www.ncbi.nlm.nih.gov/pubmed/24623960 http://dx.doi.org/10.1155/2014/195327 |
Ejemplares similares
-
Drugs that simultaneously down-regulate IL-1β and TNF secretion significantly reduce inflammation in a rat model of antigen-induced arthritis
por: Cascão, Rita, et al.
Publicado: (2011) -
Celastrol Efficacy by Oral Administration in the Adjuvant-Induced Arthritis Model
por: Cascão, Rita, et al.
Publicado: (2020) -
Effect of celastrol on bone structure and mechanics in arthritic rats
por: Cascão, Rita, et al.
Publicado: (2017) -
Arthritis Induces Early Bone High Turnover, Structural Degradation and Mechanical Weakness
por: Vidal, Bruno, et al.
Publicado: (2015) -
Correction: Arthritis Induces Early Bone High Turnover, Structural Degradation and Mechanical Weakness
por: Vidal, Bruno, et al.
Publicado: (2015)