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Elaboration versus Suppression of Cued Memories: Influence of Memory Recall Instruction and Success on Parietal Lobe, Default Network, and Hippocampal Activity

Functional imaging studies of episodic memory retrieval consistently report task-evoked and memory-related activity in the medial temporal lobe, default network and parietal lobe subregions. Associated components of memory retrieval, such as attention-shifts, search, retrieval success, and post-retr...

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Autores principales: Gimbel, Sarah I., Brewer, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929625/
https://www.ncbi.nlm.nih.gov/pubmed/24586492
http://dx.doi.org/10.1371/journal.pone.0089037
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author Gimbel, Sarah I.
Brewer, James B.
author_facet Gimbel, Sarah I.
Brewer, James B.
author_sort Gimbel, Sarah I.
collection PubMed
description Functional imaging studies of episodic memory retrieval consistently report task-evoked and memory-related activity in the medial temporal lobe, default network and parietal lobe subregions. Associated components of memory retrieval, such as attention-shifts, search, retrieval success, and post-retrieval processing also influence regional activity, but these influences remain ill-defined. To better understand how top-down control affects the neural bases of memory retrieval, we examined how regional activity responses were modulated by task goals during recall success or failure. Specifically, activity was examined during memory suppression, recall, and elaborative recall of paired-associates. Parietal lobe was subdivided into dorsal (BA 7), posterior ventral (BA 39), and anterior ventral (BA 40) regions, which were investigated separately to examine hypothesized distinctions in sub-regional functional responses related to differential attention-to-memory and memory strength. Top-down suppression of recall abolished memory strength effects in BA 39, which showed a task-negative response, and BA 40, which showed a task-positive response. The task-negative response in default network showed greater negatively-deflected signal for forgotten pairs when task goals required recall. Hippocampal activity was task-positive and was influenced by memory strength only when task goals required recall. As in previous studies, we show a memory strength effect in parietal lobe and hippocampus, but we show that this effect is top-down controlled and sensitive to whether the subject is trying to suppress or retrieve a memory. These regions are all implicated in memory recall, but their individual activity patterns show distinct memory-strength-related responses when task goals are varied. In parietal lobe, default network, and hippocampus, top-down control can override the commonly identified effects of memory strength.
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spelling pubmed-39296252014-02-25 Elaboration versus Suppression of Cued Memories: Influence of Memory Recall Instruction and Success on Parietal Lobe, Default Network, and Hippocampal Activity Gimbel, Sarah I. Brewer, James B. PLoS One Research Article Functional imaging studies of episodic memory retrieval consistently report task-evoked and memory-related activity in the medial temporal lobe, default network and parietal lobe subregions. Associated components of memory retrieval, such as attention-shifts, search, retrieval success, and post-retrieval processing also influence regional activity, but these influences remain ill-defined. To better understand how top-down control affects the neural bases of memory retrieval, we examined how regional activity responses were modulated by task goals during recall success or failure. Specifically, activity was examined during memory suppression, recall, and elaborative recall of paired-associates. Parietal lobe was subdivided into dorsal (BA 7), posterior ventral (BA 39), and anterior ventral (BA 40) regions, which were investigated separately to examine hypothesized distinctions in sub-regional functional responses related to differential attention-to-memory and memory strength. Top-down suppression of recall abolished memory strength effects in BA 39, which showed a task-negative response, and BA 40, which showed a task-positive response. The task-negative response in default network showed greater negatively-deflected signal for forgotten pairs when task goals required recall. Hippocampal activity was task-positive and was influenced by memory strength only when task goals required recall. As in previous studies, we show a memory strength effect in parietal lobe and hippocampus, but we show that this effect is top-down controlled and sensitive to whether the subject is trying to suppress or retrieve a memory. These regions are all implicated in memory recall, but their individual activity patterns show distinct memory-strength-related responses when task goals are varied. In parietal lobe, default network, and hippocampus, top-down control can override the commonly identified effects of memory strength. Public Library of Science 2014-02-19 /pmc/articles/PMC3929625/ /pubmed/24586492 http://dx.doi.org/10.1371/journal.pone.0089037 Text en © 2014 Gimbel, Brewer http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Gimbel, Sarah I.
Brewer, James B.
Elaboration versus Suppression of Cued Memories: Influence of Memory Recall Instruction and Success on Parietal Lobe, Default Network, and Hippocampal Activity
title Elaboration versus Suppression of Cued Memories: Influence of Memory Recall Instruction and Success on Parietal Lobe, Default Network, and Hippocampal Activity
title_full Elaboration versus Suppression of Cued Memories: Influence of Memory Recall Instruction and Success on Parietal Lobe, Default Network, and Hippocampal Activity
title_fullStr Elaboration versus Suppression of Cued Memories: Influence of Memory Recall Instruction and Success on Parietal Lobe, Default Network, and Hippocampal Activity
title_full_unstemmed Elaboration versus Suppression of Cued Memories: Influence of Memory Recall Instruction and Success on Parietal Lobe, Default Network, and Hippocampal Activity
title_short Elaboration versus Suppression of Cued Memories: Influence of Memory Recall Instruction and Success on Parietal Lobe, Default Network, and Hippocampal Activity
title_sort elaboration versus suppression of cued memories: influence of memory recall instruction and success on parietal lobe, default network, and hippocampal activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929625/
https://www.ncbi.nlm.nih.gov/pubmed/24586492
http://dx.doi.org/10.1371/journal.pone.0089037
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