Neuronal-Specific Deficiency of the Splicing Factor Tra2b Causes Apoptosis in Neurogenic Areas of the Developing Mouse Brain

Alternative splicing (AS) increases the informational content of the genome and is more prevalent in the brain than in any other tissue. The splicing factor Tra2b (Sfrs10) can modulate splicing inclusion of exons by specifically detecting GAA-rich binding motifs and its absence causes early embryoni...

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Detalles Bibliográficos
Autores principales: Storbeck, Markus, Hupperich, Kristina, Gaspar, John Antonydas, Meganathan, Kesavan, Martínez Carrera, Lilian, Wirth, Radu, Sachinidis, Agapios, Wirth, Brunhilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929626/
https://www.ncbi.nlm.nih.gov/pubmed/24586484
http://dx.doi.org/10.1371/journal.pone.0089020

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