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Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis
Since morbidity and mortality rates of anaphylaxis diseases have been increasing year by year, how to prevent and manage these diseases effectively has become an important issue. Mast cells play a central regulatory role in allergic diseases. Angiopoietin1 (Ang-1) exhibits anti-inflammatory properti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929638/ https://www.ncbi.nlm.nih.gov/pubmed/24586553 http://dx.doi.org/10.1371/journal.pone.0089148 |
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author | Yao, Jun-Hua Cui, Ming Li, Meng-Tao Liu, Yi-Nan He, Qi-Hua Xiao, Jun-Jun Bai, Yun |
author_facet | Yao, Jun-Hua Cui, Ming Li, Meng-Tao Liu, Yi-Nan He, Qi-Hua Xiao, Jun-Jun Bai, Yun |
author_sort | Yao, Jun-Hua |
collection | PubMed |
description | Since morbidity and mortality rates of anaphylaxis diseases have been increasing year by year, how to prevent and manage these diseases effectively has become an important issue. Mast cells play a central regulatory role in allergic diseases. Angiopoietin1 (Ang-1) exhibits anti-inflammatory properties by inhibiting vascular permeability, leukocyte migration and cytokine production. However, Ang-1's function in mast cell activation and anaphylaxis diseases is unknown. The results of our study suggest that Ang-1 decreased lipopolysaccharide (LPS)-induced pro-inflammatory cytokines production of mast cells by suppressing IκB phosphorylation and NF-κB nuclear translocation. Ang-1 also strongly inhibited compound 48/80 induced and FcεRI-mediated mast cells degranulation by decreasing intracellular calcium levels in vitro. In vivo lentivirus-mediated delivery of Ang-1 in mice exhibited alleviated leakage in IgE-dependent passive cutaneous anaphylaxis (PCA). Furthermore, exogenous Ang-1 intervention treatment prevented mice from compound 48/80-induced mesentery mast cell degranulation, attenuated increases in pro-inflammatory cytokines, relieved lung injury, and improved survival in anaphylaxis shock. The results of our study reveal, for the first time, the important role of Ang-1 in the activation of mast cells, and identify a therapeutic effect of Ang-1 on anaphylaxis diseases. |
format | Online Article Text |
id | pubmed-3929638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39296382014-02-25 Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis Yao, Jun-Hua Cui, Ming Li, Meng-Tao Liu, Yi-Nan He, Qi-Hua Xiao, Jun-Jun Bai, Yun PLoS One Research Article Since morbidity and mortality rates of anaphylaxis diseases have been increasing year by year, how to prevent and manage these diseases effectively has become an important issue. Mast cells play a central regulatory role in allergic diseases. Angiopoietin1 (Ang-1) exhibits anti-inflammatory properties by inhibiting vascular permeability, leukocyte migration and cytokine production. However, Ang-1's function in mast cell activation and anaphylaxis diseases is unknown. The results of our study suggest that Ang-1 decreased lipopolysaccharide (LPS)-induced pro-inflammatory cytokines production of mast cells by suppressing IκB phosphorylation and NF-κB nuclear translocation. Ang-1 also strongly inhibited compound 48/80 induced and FcεRI-mediated mast cells degranulation by decreasing intracellular calcium levels in vitro. In vivo lentivirus-mediated delivery of Ang-1 in mice exhibited alleviated leakage in IgE-dependent passive cutaneous anaphylaxis (PCA). Furthermore, exogenous Ang-1 intervention treatment prevented mice from compound 48/80-induced mesentery mast cell degranulation, attenuated increases in pro-inflammatory cytokines, relieved lung injury, and improved survival in anaphylaxis shock. The results of our study reveal, for the first time, the important role of Ang-1 in the activation of mast cells, and identify a therapeutic effect of Ang-1 on anaphylaxis diseases. Public Library of Science 2014-02-19 /pmc/articles/PMC3929638/ /pubmed/24586553 http://dx.doi.org/10.1371/journal.pone.0089148 Text en © 2014 Yao et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Yao, Jun-Hua Cui, Ming Li, Meng-Tao Liu, Yi-Nan He, Qi-Hua Xiao, Jun-Jun Bai, Yun Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis |
title | Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis |
title_full | Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis |
title_fullStr | Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis |
title_full_unstemmed | Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis |
title_short | Angiopoietin1 Inhibits Mast Cell Activation and Protects against Anaphylaxis |
title_sort | angiopoietin1 inhibits mast cell activation and protects against anaphylaxis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929638/ https://www.ncbi.nlm.nih.gov/pubmed/24586553 http://dx.doi.org/10.1371/journal.pone.0089148 |
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