Improvement of Chloride Transport Defect by Gonadotropin-Releasing Hormone (GnRH) in Cystic Fibrosis Epithelial Cells

Cystic fibrosis (CF), the most common autosomal recessive disease in Caucasians, is due to mutations in the CFTR gene. F508del, the most frequent mutation in patients, impairs CFTR protein folding and biosynthesis. The F508del-CFTR protein is retained in the endoplasmic reticulum (ER) and its traffi...

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Detalles Bibliográficos
Autores principales: Benz, Nathalie, Le Hir, Sophie, Norez, Caroline, Kerbiriou, Mathieu, Calvez, Marie-Laure, Becq, Frédéric, Trouvé, Pascal, Férec, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929654/
https://www.ncbi.nlm.nih.gov/pubmed/24586461
http://dx.doi.org/10.1371/journal.pone.0088964

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