FBXW7 Mutations in Patients with Advanced Cancers: Clinical and Molecular Characteristics and Outcomes with mTOR Inhibitors

PURPOSE: FBXW7 is a tumor suppressor gene responsible for the degradation of several proto-oncogenes. Preclinical data suggest that FBXW7 mutations sensitize cells to mTOR inhibitors. Clinicopathologic characteristics of cancer patients with FBXW7 mutations and their responses to mTOR inhibitors rem...

Descripción completa

Detalles Bibliográficos
Autores principales: Jardim, Denis L., Wheler, Jennifer J., Hess, Kenneth, Tsimberidou, Apostolia M., Zinner, Ralph, Janku, Filip, Subbiah, Vivek, Naing, Aung, Piha-Paul, Sarina A., Westin, Shannon N., Roy-Chowdhuri, Sinchita, Meric-Bernstam, Funda, Hong, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929689/
https://www.ncbi.nlm.nih.gov/pubmed/24586741
http://dx.doi.org/10.1371/journal.pone.0089388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929689/
https://www.ncbi.nlm.nih.gov/pubmed/24586741
http://dx.doi.org/10.1371/journal.pone.0089388

Ejemplares similares