STK31/TDRD8, a Germ Cell-Specific Factor, Is Dispensable for Reproduction in Mice

Tudor domain containing (Tdrd) proteins that are expressed in germ cells are divided into two groups. One group, consisting of TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing, while the other group including RNF17/TDRD4 and TDRD5-7 are required for spermiog...

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Detalles Bibliográficos
Autores principales: Zhou, Jian, Leu, N. Adrian, Eckardt, Sigrid, McLaughlin, K. John, Wang, P. Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929691/
https://www.ncbi.nlm.nih.gov/pubmed/24586802
http://dx.doi.org/10.1371/journal.pone.0089471
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author Zhou, Jian
Leu, N. Adrian
Eckardt, Sigrid
McLaughlin, K. John
Wang, P. Jeremy
author_facet Zhou, Jian
Leu, N. Adrian
Eckardt, Sigrid
McLaughlin, K. John
Wang, P. Jeremy
author_sort Zhou, Jian
collection PubMed
description Tudor domain containing (Tdrd) proteins that are expressed in germ cells are divided into two groups. One group, consisting of TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing, while the other group including RNF17/TDRD4 and TDRD5-7 are required for spermiogenesis. These Tdrd proteins play distinct roles during male germ cell development. Here, we report the characterization of STK31/TDRD8 in mice. STK31 contains a tudor domain and a serine/threonine kinase domain. We find that STK31 is a cytoplasmic protein in germ cells. STK31 is expressed in embryonic gonocytes of both sexes and postnatal spermatocytes and round spermatids in males. Disruption of the tudor domain and kinase domain of STK31 respectively does not affect fertility in mice. Our data suggest that the function of STK31 may be redundant with other Tdrd proteins in germ cell development.
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spelling pubmed-39296912014-02-25 STK31/TDRD8, a Germ Cell-Specific Factor, Is Dispensable for Reproduction in Mice Zhou, Jian Leu, N. Adrian Eckardt, Sigrid McLaughlin, K. John Wang, P. Jeremy PLoS One Research Article Tudor domain containing (Tdrd) proteins that are expressed in germ cells are divided into two groups. One group, consisting of TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing, while the other group including RNF17/TDRD4 and TDRD5-7 are required for spermiogenesis. These Tdrd proteins play distinct roles during male germ cell development. Here, we report the characterization of STK31/TDRD8 in mice. STK31 contains a tudor domain and a serine/threonine kinase domain. We find that STK31 is a cytoplasmic protein in germ cells. STK31 is expressed in embryonic gonocytes of both sexes and postnatal spermatocytes and round spermatids in males. Disruption of the tudor domain and kinase domain of STK31 respectively does not affect fertility in mice. Our data suggest that the function of STK31 may be redundant with other Tdrd proteins in germ cell development. Public Library of Science 2014-02-19 /pmc/articles/PMC3929691/ /pubmed/24586802 http://dx.doi.org/10.1371/journal.pone.0089471 Text en © 2014 Zhou et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhou, Jian
Leu, N. Adrian
Eckardt, Sigrid
McLaughlin, K. John
Wang, P. Jeremy
STK31/TDRD8, a Germ Cell-Specific Factor, Is Dispensable for Reproduction in Mice
title STK31/TDRD8, a Germ Cell-Specific Factor, Is Dispensable for Reproduction in Mice
title_full STK31/TDRD8, a Germ Cell-Specific Factor, Is Dispensable for Reproduction in Mice
title_fullStr STK31/TDRD8, a Germ Cell-Specific Factor, Is Dispensable for Reproduction in Mice
title_full_unstemmed STK31/TDRD8, a Germ Cell-Specific Factor, Is Dispensable for Reproduction in Mice
title_short STK31/TDRD8, a Germ Cell-Specific Factor, Is Dispensable for Reproduction in Mice
title_sort stk31/tdrd8, a germ cell-specific factor, is dispensable for reproduction in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929691/
https://www.ncbi.nlm.nih.gov/pubmed/24586802
http://dx.doi.org/10.1371/journal.pone.0089471
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