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Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges

Cerebral autoregulation (CA) is integral to the delicate process of maintaining stable cerebral perfusion and brain tissue oxygenation against changes in arterial blood pressure. The last four decades has seen dramatic advances in understanding CA physiology, and the role that CA might play in the c...

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Detalles Bibliográficos
Autores principales: Tzeng, Yu-Chieh, Ainslie, Philip N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929776/
https://www.ncbi.nlm.nih.gov/pubmed/23737006
http://dx.doi.org/10.1007/s00421-013-2667-y
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author Tzeng, Yu-Chieh
Ainslie, Philip N.
author_facet Tzeng, Yu-Chieh
Ainslie, Philip N.
author_sort Tzeng, Yu-Chieh
collection PubMed
description Cerebral autoregulation (CA) is integral to the delicate process of maintaining stable cerebral perfusion and brain tissue oxygenation against changes in arterial blood pressure. The last four decades has seen dramatic advances in understanding CA physiology, and the role that CA might play in the causation and progression of disease processes that affect the cerebral circulation such as stroke. However, the translation of these basic scientific advances into clinical practice has been limited by the maintenance of old constructs and because there are persistent gaps in our understanding of how this vital vascular mechanism should be quantified. In this review, we re-evaluate relevant studies that challenge established paradigms about how the cerebral perfusion pressure and blood flow are related. In the context of blood pressure being a major haemodynamic challenge to the cerebral circulation, we conclude that: (1) the physiological properties of CA remain inconclusive, (2) many extant methods for CA characterisation are based on simplistic assumptions that can give rise to misleading interpretations, and (3) robust evaluation of CA requires thorough consideration not only of active vasomotor function, but also the unique properties of the intracranial environment.
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spelling pubmed-39297762014-02-25 Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges Tzeng, Yu-Chieh Ainslie, Philip N. Eur J Appl Physiol Invited Review Cerebral autoregulation (CA) is integral to the delicate process of maintaining stable cerebral perfusion and brain tissue oxygenation against changes in arterial blood pressure. The last four decades has seen dramatic advances in understanding CA physiology, and the role that CA might play in the causation and progression of disease processes that affect the cerebral circulation such as stroke. However, the translation of these basic scientific advances into clinical practice has been limited by the maintenance of old constructs and because there are persistent gaps in our understanding of how this vital vascular mechanism should be quantified. In this review, we re-evaluate relevant studies that challenge established paradigms about how the cerebral perfusion pressure and blood flow are related. In the context of blood pressure being a major haemodynamic challenge to the cerebral circulation, we conclude that: (1) the physiological properties of CA remain inconclusive, (2) many extant methods for CA characterisation are based on simplistic assumptions that can give rise to misleading interpretations, and (3) robust evaluation of CA requires thorough consideration not only of active vasomotor function, but also the unique properties of the intracranial environment. Springer Berlin Heidelberg 2013-06-05 2014 /pmc/articles/PMC3929776/ /pubmed/23737006 http://dx.doi.org/10.1007/s00421-013-2667-y Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Invited Review
Tzeng, Yu-Chieh
Ainslie, Philip N.
Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges
title Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges
title_full Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges
title_fullStr Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges
title_full_unstemmed Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges
title_short Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges
title_sort blood pressure regulation ix: cerebral autoregulation under blood pressure challenges
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929776/
https://www.ncbi.nlm.nih.gov/pubmed/23737006
http://dx.doi.org/10.1007/s00421-013-2667-y
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