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Temporally selective contextual encoding in the dentate gyrus of the hippocampus

A recent model of the hippocampus predicts that the unique properties of the dentate gyrus allow for temporal separation of events. This temporal separation is accomplished in part through the continual generation of new neurons, which, due to a transient window of hyperexcitability, could allow for...

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Detalles Bibliográficos
Autores principales: Rangel, L.M., Alexander, A.S., Aimone, J.B., Wiles, J., Gage, F.H., Chiba, A.A., Quinn, L.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929785/
https://www.ncbi.nlm.nih.gov/pubmed/24518986
http://dx.doi.org/10.1038/ncomms4181
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author Rangel, L.M.
Alexander, A.S.
Aimone, J.B.
Wiles, J.
Gage, F.H.
Chiba, A.A.
Quinn, L.K.
author_facet Rangel, L.M.
Alexander, A.S.
Aimone, J.B.
Wiles, J.
Gage, F.H.
Chiba, A.A.
Quinn, L.K.
author_sort Rangel, L.M.
collection PubMed
description A recent model of the hippocampus predicts that the unique properties of the dentate gyrus allow for temporal separation of events. This temporal separation is accomplished in part through the continual generation of new neurons, which, due to a transient window of hyperexcitability, could allow for preferential encoding of information present during their development. Here we obtain in vivo electrophysiological recordings and identify a cell population exhibiting activity that is selective to single contexts when rats experience a long temporal separation between context exposures during training. This selectivity is attenuated as the temporal separation between context exposures is shortened and is further attenuated when neurogenesis is reduced. Our data reveal the existence of a temporal orthogonalizing neuronal code within the dentate gyrus, a hallmark feature of episodic memory.
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spelling pubmed-39297852014-02-21 Temporally selective contextual encoding in the dentate gyrus of the hippocampus Rangel, L.M. Alexander, A.S. Aimone, J.B. Wiles, J. Gage, F.H. Chiba, A.A. Quinn, L.K. Nat Commun Article A recent model of the hippocampus predicts that the unique properties of the dentate gyrus allow for temporal separation of events. This temporal separation is accomplished in part through the continual generation of new neurons, which, due to a transient window of hyperexcitability, could allow for preferential encoding of information present during their development. Here we obtain in vivo electrophysiological recordings and identify a cell population exhibiting activity that is selective to single contexts when rats experience a long temporal separation between context exposures during training. This selectivity is attenuated as the temporal separation between context exposures is shortened and is further attenuated when neurogenesis is reduced. Our data reveal the existence of a temporal orthogonalizing neuronal code within the dentate gyrus, a hallmark feature of episodic memory. Nature Pub. Group 2014-02-12 /pmc/articles/PMC3929785/ /pubmed/24518986 http://dx.doi.org/10.1038/ncomms4181 Text en Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/3.0/ This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. To view a copy of this licence visit http://creativecommons.org/licenses/by/3.0/.
spellingShingle Article
Rangel, L.M.
Alexander, A.S.
Aimone, J.B.
Wiles, J.
Gage, F.H.
Chiba, A.A.
Quinn, L.K.
Temporally selective contextual encoding in the dentate gyrus of the hippocampus
title Temporally selective contextual encoding in the dentate gyrus of the hippocampus
title_full Temporally selective contextual encoding in the dentate gyrus of the hippocampus
title_fullStr Temporally selective contextual encoding in the dentate gyrus of the hippocampus
title_full_unstemmed Temporally selective contextual encoding in the dentate gyrus of the hippocampus
title_short Temporally selective contextual encoding in the dentate gyrus of the hippocampus
title_sort temporally selective contextual encoding in the dentate gyrus of the hippocampus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929785/
https://www.ncbi.nlm.nih.gov/pubmed/24518986
http://dx.doi.org/10.1038/ncomms4181
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